PMID: 7993305Sep 1, 1994Paper

Intrahippocampal administration of both the D- and the L-isomers of AP5 disrupt spontaneous alternation behavior and evoked potentials

Behavioral and Neural Biology
D L Walker, P E Gold

Abstract

We previously reported that systemically administered N-methyl-D-aspartate (NMDA) antagonists significantly impair spontaneous alternation behavior. Others have reported that the restricted blockade of hippocampal NMDA receptors disrupts performance on different tests of spatial learning and have suggested that the resulting impairments are attributable to a disruption of endogenous NMDA-dependent long-term potentiation (LTP). In the present study, we determined whether spontaneous alternation performance was disrupted by circumscribed blockade of hippocampal NMDA receptors as well as by a second class of compounds which disrupt LTP, protein kinase inhibitors. The effect of hippocampal NMDA blockade on inhibitory avoidance was also examined insofar as this behavior too is disrupted by systemically administered NMDA antagonists. When injected into the hippocampus 15 min prior to spontaneous alternation testing, the NMDA antagonists CPP and D,L-AP5 each decreased alternation rates. The specific protein kinase C (PKC) inhibitor, NPC 15437, also disrupted spontaneous alternation, whereas the more general kinase inhibitor, PMXB, did not. When injected 15 min prior to inhibitory avoidance training, CPP also impaired inhibitory avoida...Continue Reading

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Citations

Nov 1, 1995·Behavioural Brain Research·E I Moser
May 1, 1997·Pharmacology, Biochemistry, and Behavior·D A JettT R Guilarte
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·C J SlaweckiC L Ehlers
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Apr 1, 1997·Current Opinion in Neurobiology·D P Cain
Sep 29, 2004·Toxicology and Applied Pharmacology·Adrinel Vázquez, Sandra Peña de Ortiz
Jan 5, 2002·Hippocampus·R P Kesner, E T Rolls

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