PMID: 9553168May 30, 1998Paper

Intraindividual comparison of 99mTc-labelled anti-SSEA-1 antigranulocyte antibody and 99mTc-HMPAO labelled white blood cells for the imaging of infection

European Journal of Nuclear Medicine
S GratzW S Becker

Abstract

Technetium-99m labelled antigranulocyte antibodies are ready to use and are sensitive and specific in the diagnosis of infectious diseases. 99mTc-SSEA antigranulocyte antibodies have a very high affinity constant (Kd 10(-12) M) for human neutrophils (PMNs), and excellent imaging qualities with high target/background ratios. The aim of this study was to compare the diagnostic accuracy of the 99mTc-anti-SSEA-1 monoclonal antibody (Mab) with that of 99mTc-hexamethylpropylene amine oxime (HMPAO)-labelled white blood cells (WBCs). To this end, 17 patients with 23 proven infectious foci were examined with 555 MBq 99mTc-anti-SSEA-1 MAb and with 370 MBq 99mTc-HMPAO labelled autologous leucocytes within a period of 7 days. All the infections were confirmed by culture, biopsy, surgery and follow-up. Whole-body images and planar spot views with the antibody were performed at 1-h, 4-h and 24-h post injection; the biodistribution of the antibody was quantified, absorbed radiation doses were calculated and the diagnostic results were compared with the 99mTc-HMPAO WBC images. Human anti-mouse antibody (HAMA) evaluation was performed in all patients before and 3 months after antibody injection. Blood was drawn at different times after 99mTc-an...Continue Reading

Citations

Aug 13, 2011·Annals of Nuclear Medicine·Alberto Signore, Andor W J M Glaudemans
Feb 24, 2001·Nuclear Medicine Communications·P S RaoM L Thakur
Jun 5, 2001·Nuclear Medicine Communications·M L ThakurT Smith
Jul 11, 2006·Nuclear Medicine Communications·Napoleone PrandiniAlberto Signore
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Jun 3, 2021·Journal of Fungi·Alfred O AnkrahAndor W J M Glaudemans
Oct 13, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Doreen LauFerdia A Gallagher

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