Intraintestinal Delivery of Tastants Using a Naso-Duodenal-Ileal Catheter Does Not Influence Food Intake or Satiety

Nutrients
Tim KlaassenAdrian Am Masclee

Abstract

Intraduodenal activity of taste receptors reduces food intake. Taste receptors are expressed throughout the entire gastrointestinal tract. Currently, there are no data available on the effects of distal taste receptor activation. In this study, we investigate the effect of intraduodenal and/or intraileal activation of taste receptors on food intake and satiety. In a single-blind randomized crossover trial, fourteen participants were intubated with a naso-duodenal-ileal catheter and received four infusion regimens: duodenal placebo and ileal placebo (DPIP), duodenal tastants and ileal placebo (DTIP), duodenal placebo and ileal tastants (DPIT), duodenal tastants and ileal tastants (DTIT). Fifteen minutes after cessation of infusion, subjects received an ad libitum meal to measure food intake. Visual analog scale scores for satiety feelings were collected at regular intervals. No differences in food intake were observed between the various interventions (DPIP: 786.6 ± 79.2 Kcal, DTIP: 803.3 ± 69.0 Kcal, DPIT: 814.7 ± 77.3 Kcal, DTIT: 834.8 ± 59.2 Kcal, p = 0.59). No differences in satiety feelings were observed. Intestinal infusion of tastants using a naso-duodenal-ileal catheter did not influence food intake or satiety feelings. ...Continue Reading

References

Feb 13, 2001·Neuroscience and Biobehavioral Reviews·J E SteinerK C Berridge
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·S Vincent WuEnrique Rozengurt
May 27, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nora RozengurtEnrique Rozengurt
Oct 13, 2006·Chemical Senses·Carole BezençonSami Damak
Feb 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kate SutherlandL Ashley Blackshaw
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hyeung-Jin JangJosephine M Egan
Jan 11, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Catia SterniniEnrique Rozengurt
Feb 28, 2008·Current Biology : CB·Paul A S Breslin, Alan C Spector
Aug 12, 2008·Physiology & Behavior·P W J MaljaarsA A M Masclee
Sep 17, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P W J MaljaarsA A M Masclee
Mar 10, 2009·The British Journal of Nutrition·Natalie D Luscombe-MarshMargriet S Westerterp-Plantenga
Aug 6, 2013·Physiology & Behavior·H S ShinS D Poppitt
Jun 25, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M van AvesaatA A M Masclee
Jun 14, 2015·Biochemical and Biophysical Research Communications·Fu GuFeng Li
Aug 21, 2015·The American Journal of Clinical Nutrition·Mark van AvesaatAd Am Masclee
Nov 5, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M van AvesaatF J Troost
Aug 5, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E DelooseJ Tack

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Citations

Jan 16, 2020·Nutrients·Beverly J Tepper, Iole Tomassini Barbarossa
May 25, 2021·American Journal of Physiology. Endocrinology and Metabolism·Wout VerbeureJan Tack

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