Intralesional immunotherapy for the treatment of warts: A network meta-analysis

Journal of the American Academy of Dermatology
Samar SalmanAbdelrahman Ibrahim Abushouk

Abstract

Without clear evidence, selecting among the existing immunotherapeutic options for warts remains challenging. Through network meta-analyses, we aimed to evaluate the comparative efficacy of different intralesional immunotherapeutic modalities. We included randomized controlled trials comparing intralesional immunotherapeutic modalities to cryotherapy, placebo, or imiquimod. All outcomes were presented as odds ratios (ORs) with 95% confidence intervals. Both conventional and network meta-analyses (with a frequentist approach) were conducted on R software. The P-score was used to rank different treatments. Network meta-analysis of 17 randomized controlled trials (1676 patients) showed that PPD (purified protein derivative vaccine, OR 39.56), MMR (measles, mumps, rubella vaccine, OR 17.46) and interferon β (OR 15.55) had the highest efficacy in terms of complete recovery at the primary site compared with placebo. Regarding complete recovery at the distant site, autoinoculation (OR 79.95), PPD (OR 42.95), and MMR (OR 15.39) were all statistically superior to placebo. According to the P-score, MMR was more effective than other modalities in reducing the recurrence rate at the same site. Relatively small sample size in some compariso...Continue Reading

Associated Clinical Trials

Citations

Mar 1, 2020·International Journal of Dermatology·Sowmya KaimalVenkatesh Premalatha
Mar 3, 2020·The Journal of Dermatological Treatment·Kanchana LeerunyakulSuthinee Rutnin
Jun 13, 2020·Dermatologic Therapy·Mohamed M FawzyRania Alakad
Jul 1, 2021·Indian Journal of Dermatology·Amandeep KaurNeerja Puri

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