PMID: 16276163Nov 9, 2005

Intralesional methotrexate for keratoacanthoma of the nose

Skinmed
Philip R CohenB R Nelson

Abstract

A 56-year-old woman developed a nodule on her nose. A shave biopsy of the enlarging lesion was performed after 2 weeks and showed a keratoacanthoma. During the subsequent 4 weeks, the lesion continued to grow rapidly, and she was referred for excision of the lesion using the Mohs microscopically controlled technique. A tender 10x12 mm (120 mm2) erythematous nodule with a keratin-filled central umbilication was present on her left nasal ala (Figure 1). Treatment options were discussed. The left nasal ala was locally anesthetized with 1% lidocaine with 1:100,000 epinephrine and the keratoacanthoma was circumferentially infiltrated with 10 mg of methotrexate (0.8 mL of 12.5 mg/mL methotrexate) using a 30-gauge needle. The total amount of methotrexate injected was divided among several injection sites: the peripheral shoulder of the lesion (such that there was blanching of the entire rim) and under the center of the lesion at a depth clinically judged to be the deepest area of involvement. Within the next 7 days, the tumor began to decrease in size and ulcerate centrally. Examination 2 weeks after the initial injection showed a 71% reduction in the area of the tumor, which now measured 35 mm2 (7.0x5.0 mm). The tumor was injected in...Continue Reading

References

Dec 1, 1991·Journal of the American Academy of Dermatology·J L MeltonT M Johnson
Jan 1, 1991·The Australasian Journal of Dermatology·J A Nedwich
Aug 1, 1991·Journal of the American Academy of Dermatology·E A Olsen
Sep 1, 1990·Journal of the American Academy of Dermatology·B DonahueS Rush
Nov 1, 1990·Journal of the American Academy of Dermatology·L H GoldbergA Knauss
May 1, 1987·Journal of the American Academy of Dermatology·P O Larson
Jan 1, 1989·Journal of the American Academy of Dermatology·L WickramasingheH Wacks
May 1, 1986·Journal of the American Academy of Dermatology·C M Parker, C W Hanke
Jul 1, 1966·Archives of Dermatology·W M Tarnowski
Nov 1, 1973·Archives of Dermatology·J L Kestel, D S Blair
May 1, 1971·Archives of Dermatology·A W Kopf
Mar 1, 1980·Journal of the American Academy of Dermatology·D K Goette, R B Odom
Jun 1, 1995·British Journal of Plastic Surgery·L N Hurst, B S Gan
Aug 1, 1993·Journal of the American Academy of Dermatology·J J GrobJ J Bonerandi
May 15, 1998·Archives of Dermatology·C Cuesta-Romero, J de Grado-Peña
Aug 18, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·M AgarwalR Walia
May 3, 2000·The British Journal of Dermatology·J E ConsigliS Maldonado
Jul 15, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·K SpiethR Kaufmann
Jan 5, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jan G A M de VisscherFeike Willemse
Nov 2, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Scott SandersKishwer S Nehal
Jan 17, 2004·Journal of the American Academy of Dermatology·Frank C Saporito, M Alan Menter
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Schwartz
Apr 21, 2004·Journal of the American Academy of Dermatology·Leonard H GoldbergMurad Alam

Citations

Sep 18, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jason C HadleyMichael L Hadley
Jul 8, 2010·Journal of the American Academy of Dermatology·Joslyn S Kirby, Christopher J Miller
May 17, 2007·Journal of the American Academy of Dermatology·Nicole M AnnestDuane C Whitaker
Jan 14, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Hayriye SarıcaogluHakan Turan
Mar 14, 2019·Dermatologic Therapy·Norbert KissNorbert Wikonkál
Oct 9, 2019·Journal of Cutaneous Medicine and Surgery·Edward W SegerTing Wang
Oct 13, 2020·Dermatologic Therapy·Tamara SearleFiras Al-Niaimi

Related Concepts

Antimetabolites, Antineoplastic
Keratoacanthoma
Methotrexate, (DL)-Isomer
Nose Diseases
Injections, Intralesional

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