Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature

Journal of the American Academy of Dermatology
Nicole M AnnestDuane C Whitaker

Abstract

Intralesional methotrexate (MTX) is an effective treatment for keratoacanthoma (KA). We sought to systematically examine response rates and adverse events in KA treated with intralesional MTX. All cases of KA treated with intralesional MTX at our institution from 1991 to 2006 were identified. A MEDLINE and PubMed search of cases of KA treated with intralesional MTX was also performed. In all, 38 cases of KA treated with intralesional MTX were identified: 18 from our institution and 20 from the literature. Intralesional MTX achieved resolution in 92%, requiring an average of 2.1 injections an average of 18 days apart. Adverse events were rare, with two reports of pancytopenia in patients with chronic renal failure. Use of single case reports, small series, and retrospective analysis are limitations. Intralesional MTX is a useful nonsurgical therapy for the treatment of KA. Histologic diagnosis before initiation of treatment is preferred. A complete blood cell count at baseline and during treatment should be considered to monitor for potential cytopenia.

References

Jan 1, 1977·Dermatologica·F Reymann
Dec 1, 1991·Journal of the American Academy of Dermatology·J L MeltonT M Johnson
Jan 1, 1991·The Australasian Journal of Dermatology·J A Nedwich
Aug 1, 1991·Journal of the American Academy of Dermatology·E A Olsen
May 1, 1987·Journal of the American Academy of Dermatology·P O Larson
Feb 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M Caccialanza, N Sopelana
Jan 1, 1986·Ophthalmic Plastic and Reconstructive Surgery·D J BerginT A Deffer
May 1, 1986·Journal of the American Academy of Dermatology·C M Parker, C W Hanke
Jun 1, 1995·British Journal of Plastic Surgery·L N Hurst, B S Gan
Aug 1, 1994·International Journal of Dermatology·W Y WongA Guana
Sep 1, 1994·Journal of the American Academy of Dermatology·L BenestR Moy
Aug 1, 1993·Journal of the American Academy of Dermatology·J J GrobJ J Bonerandi
Sep 1, 1993·Archives of Dermatology·H Goldschmidt, W K Sherwin
May 15, 1998·Archives of Dermatology·C Cuesta-Romero, J de Grado-Peña
May 26, 1998·Annals of Plastic Surgery·C H MansteinJ E Besden
Mar 15, 2000·The Australasian Journal of Dermatology·A T Sheridan, R P Dawber
Jul 15, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·K SpiethRoland Kaufmann
Nov 18, 2003·The British Journal of Dermatology·M GoebelerD Zillikens
Dec 4, 2004·Journal of the American Academy of Dermatology·Chang-Keun OhKyung-Sool Kwon
Nov 9, 2005·Skinmed·Philip R CohenBruce R Nelson
Nov 6, 2009·The British Journal of Dermatology·M GrahovacA Wollenberg

Citations

Mar 27, 2009·HNO·M Braun-Falco
May 5, 2010·Plastic and Reconstructive Surgery·Erica H LeeJoseph J Disa
Aug 7, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Katelyn ChitwoodGeorge Cohen
Aug 7, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R Salido-VallejoJ C Moreno-Giménez
Feb 9, 2016·Journal of the American Academy of Dermatology·Bartlomiej Kwiek, Robert A Schwartz
Jul 8, 2010·Journal of the American Academy of Dermatology·Joslyn S Kirby, Christopher J Miller
Mar 26, 2010·Journal of the American Academy of Dermatology·Laurie M GoodWhitney A High
Sep 16, 2008·Annales de dermatologie et de vénéréologie·B Cribier
Jan 5, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ioannis Manousaridis, Martin Leverkus
Dec 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J J BonerandiFrench Dermatology Recommendations Association (aRED)
Feb 22, 2011·The Australasian Journal of Dermatology·Glen Foxton, Tom Delaney
Dec 1, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·V AnyfantakisG Guillet
Sep 16, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R Salido-VallejoJ C Moreno-Giménez
Jul 30, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander J StratigosEuropean Organization for Research and Treatment of Cancer (EORTC)
Aug 4, 2016·JAAD Case Reports·Amy Kalowitz BieberJennifer A Stein
Apr 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Molly S MoyeMarta J Van Beek
Mar 16, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anthony M RossiKishwer S Nehal
Jan 14, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Hayriye SarıcaogluHakan Turan
Sep 13, 2011·Annals of Dermatology·Hye Chan JeonKwang Hyun Cho
Jun 15, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Ketty PerisItalian Group of Dermato-Oncology (GIDO) of SIDeMaST
Mar 24, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kimberly N FlynnDouglas L Smith
Mar 14, 2019·Dermatologic Therapy·Norbert KissNorbert Wikonkál
Dec 25, 2013·The American Journal of Dermatopathology·Jacqueline A Savage, John C Maize
Oct 9, 2019·Journal of Cutaneous Medicine and Surgery·Edward W SegerTing Wang
Jan 5, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Max MossAndrew D Montemarano
Dec 24, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David PantherCathy Macknet
Sep 11, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cinzia CarriereKlaus Eisendle
Sep 29, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cinzia CarriereKlaus Eisendle
Sep 25, 2015·Medicine·Caroline Siviero DillenburgCristiane Helena Squarize
Aug 7, 2019·Experimental and Therapeutic Medicine·Roxana-Ioana NedelcuSabina Andrada Zurac
Dec 10, 2019·Case Reports in Dermatological Medicine·Georgios Gaitanis, Ioannis D Bassukas
Jun 21, 2012·Journal of Cutaneous Medicine and Surgery·Nicolas AubutJoël Claveau
Oct 18, 2015·Experimental Dermatology·Tobias GleichDaniel Hohl
Feb 23, 2019·Dermatology and Therapy·Massimiliano ScalvenziNicola Balato
Oct 13, 2020·Dermatologic Therapy·Tamara SearleFiras Al-Niaimi
Dec 1, 2020·The Australasian Journal of Dermatology·Marta Bergón-SendínRicardo Suárez-Fernández
Sep 17, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·C ConfortiIris Zalaudek
Mar 3, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander J StratigosEuropean Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Rese

Related Concepts

Antimetabolites, Antineoplastic
Injectables
Keratoacanthoma
Methotrexate, (DL)-Isomer
Retrospective Studies
Retreatments

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