Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective case series

Journal of Cutaneous Medicine and Surgery
Nicolas AubutJoël Claveau

Abstract

Intralesional methotrexate (IL-MTX) is an effective treatment for keratoacanthoma. We sought to determine the response rates and adverse events in KA treated with intralesional methotrexate. All cases of KA treated with intralesional methotrexate at our institutions from 2001 to 2009 were systematically reviewed. Forty-six cases of KA treated with IL-MTX were identified. A complete resolution was achieved in 74% of patients, requiring an average of 1.8 injection sessions, for a mean total dose of 10 mg. Adverse events did not occur. The follow-up period was short, and there was no histologic confirmation of the initial diagnosis. IL-MTX is an effective and well-tolerated alternative to surgery for the treatment of KA.

References

Dec 1, 1991·Journal of the American Academy of Dermatology·J L MeltonT M Johnson
Jan 1, 1991·The Australasian Journal of Dermatology·J A Nedwich
Aug 1, 1991·Journal of the American Academy of Dermatology·E A Olsen
May 1, 1987·Journal of the American Academy of Dermatology·P O Larson
May 1, 1986·Journal of the American Academy of Dermatology·C M Parker, C W Hanke
Feb 1, 1984·Journal of the American Academy of Dermatology·M A Goldenhersh, T G Olsen
Jun 1, 1995·British Journal of Plastic Surgery·L N Hurst, B S Gan
Aug 1, 1994·International Journal of Dermatology·W Y WongA Guana
May 15, 1998·Archives of Dermatology·C Cuesta-Romero, J de Grado-Peña
May 26, 1998·Annals of Plastic Surgery·C H MansteinJ E Besden
Jul 15, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·K SpiethR Kaufmann
Sep 21, 2000·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R RemlingJ Ring
Jan 5, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jan G A M de VisscherFeike Willemse
May 17, 2007·Journal of the American Academy of Dermatology·Nicole M AnnestDuane C Whitaker
Aug 28, 2007·Acta Dermato-venereologica·Dagmar Wilsmann-TheisMonika H Schmid-Wendtner
Jan 2, 2010·Seminars in Diagnostic Pathology·Joshua C Mandrell, Daniel Santa Cruz

Citations

Mar 14, 2019·Dermatologic Therapy·Norbert KissNorbert Wikonkál
Sep 29, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cinzia CarriereKlaus Eisendle
Dec 25, 2013·The American Journal of Dermatopathology·Jacqueline A Savage, John C Maize
Sep 11, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cinzia CarriereKlaus Eisendle
Oct 13, 2020·Dermatologic Therapy·Tamara SearleFiras Al-Niaimi

Related Concepts

Antimetabolites, Antineoplastic
Methotrexate, (DL)-Isomer
Retrospective Studies
Injections, Intralesional
Keratoacanthoma
Methotrexate
Operative Surgical Procedures
Adverse Event
Follow-up
MTX1

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
K SpiethR Kaufmann
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Kimberly N FlynnDouglas L Smith
The British Journal of Dermatology
S Sayama, H Tagami
© 2021 Meta ULC. All rights reserved