Intralesional Sclerotherapy with Bleomycin in Lymphatic Malformation of Tongue an Institutional Experience and Outcomes

Journal of Indian Association of Pediatric Surgeons
Gaurav ParasharRamesh Santhanakrishnan

Abstract

The management of lymphatic malformations (LMs) continues to improve with advancement in molecular genetics, imaging, and treatment options. However, the management of tongue LMs remains a challenge due to the location, function involved, and long-term disabilities. We propose injection sclerotherapy with bleomycin in the management of spectrum of tongue LMs. Children with LMs involving the tongue were prospectively treated with bleomycin sclerotherapy. Outcome measured was the efficacy of sclerotherapy, complications, and functional outcome. A total of 11 children underwent sclerotherapy with bleomycin for varying tongue lesions. Excellent outcome was seen in children with macroglossia. Eight children with isolated (focal) lesions had a resolution of symptoms with a clearance of lesions. Specific complications related to bleomycin toxicity were not encountered in our series during the follow-up of 4 years. In our series, children with macroglossia had an excellent outcome with normalization of tongue size and function. Children with focal tongue lesions also had good to excellent outcome. We recommend treatment of tongue LM with bleomycin sclerotherapy as the first line of management. Ease of treatment, early intervention, and...Continue Reading

References

Nov 1, 1991·The Journal of Laryngology and Otology·A Balakrishnan, C M Bailey
Jul 1, 1995·American Journal of Otolaryngology·M W SungJ Y Kim
Jun 7, 2003·International Journal of Pediatric Otorhinolaryngology·I SanlialpN Büyükpamukçu
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Jun 5, 2013·International Journal of Pediatric Otorhinolaryngology·A Chakravarti, R Bhargava

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Citations

Apr 7, 2020·Lymphatic Research and Biology·Francine Blei
Sep 5, 2020·CVIR Endovascular·Craig R Gibson, Alex M Barnacle
Aug 5, 2020·Clinical Oral Investigations·Caio César da Silva BarrosÉricka Janine Dantas da Silveira
Jul 24, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Eugenio De CorsoGaetano Paludetti

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