Keratoacanthoma (KA) is a common epidermal tumor that originates from the hair follicle of the skin. It is generally considered as a benign neoplasm, but in rare cases, it can also transform into squamous cell carcinoma. Although surgical excision with a safety margin is considered to be the gold standard treatment for most subtypes of KA, several other treatment options are also available. Intralesional therapy is one of these options, which could be cosmetically and functionally a better alternative to surgical removal, while it provides similar outcomes. It is more effective than topical treatments, yet fewer side effects may be seen than in systemic treatments. Based on the literature, the most commonly used intralesional agent is methotrexate, followed by 5-fluorouracil and interferon alpha. Regardless of the advantages, which make intralesional therapy a desirable treatment alternative, guidelines for the intralesional treatment of KA are not yet established. A histopathological confirmation before the start of treatment is still recommended to prevent any possible misdiagnosis of KA for SCC. In our present study, we set out to review the current state of the art of the intralesional treatment of KA.
Fluocinolone acetonide: a potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis
Bleomycin-lidocaine mixture reduces pain of intralesional injection in the treatment of recalcitrant verrucae
Autocrine stimulation of interleukin-1 alpha and transforming growth factor alpha production in human keratinocytes and its antagonism by glucocorticoids
Brief review of keratoacanthomas and description of keratoacanthoma centrifugum marginatum, another variety of keratoacanthoma
Intralesional methotrexate as effective treatment in solitary giant keratoacanthoma of the lower lip
Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities
Treatment of giant keratoacanthoma of the skin of the lower lip with intralesional methotrexate: a case report
The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals
Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature
Giant keratoacanthoma-type low-grade squamous cell carcinoma of the upper lip: Response to intralesional interferon alpha-2B
A novel therapeutic combination approach for treating multiple vemurafenib-induced keratoacanthomas: systemic acitretin and intralesional fluorouracil
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk
Intralesional methotrexate for the treatment of keratoacanthoma: retrospective study and review of the korean literature
Natural course of keratoacanthoma and related lesions after partial biopsy: clinical analysis of 66 lesions
Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head
The current role of in vivo reflectance confocal microscopy within the continuum of actinic keratosis and squamous cell carcinoma: a systematic review
Intralesional Methotrexate for the Treatment of Advanced Keratinocytic Tumors: A Multi-Center Retrospective Study.
Histological findings after intralesional methotrexate treatment in cutaneous squamous cell carcinoma
The first report of diagnosing of keratoacanthoma in Chinese Han patients using dermoscopy and reflectance confocal microscopy
Carcinoma, Squamous Cell
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