Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts

Journal of the American Academy of Dermatology
Ahmad NofalManal Nabil

Abstract

Despite the availability of different therapeutic modalities, treatment of recalcitrant common warts is still challenging. Cervarix (GlaxoSmithKline, Brentford, UK), a recombinant bivalent human papillomavirus (HPV) vaccine, has shown promising efficacy in the treatment of warts. To evaluate the beneficial effects and tolerability of intramuscular versus intralesional bivalent HPV vaccine in the treatment of recalcitrant common warts. The study included 44 adult patients with multiple recalcitrant common warts; 22 patients received intramuscular injection of bivalent HPV vaccine at 0, 1, and 6 months or until complete clearance of warts, and the other 22 patients received intralesional injection of 0.1 to 0.3 mL of bivalent HPV vaccine into the largest wart at 2-week intervals until complete clearance or for a maximum of 6 sessions. Complete clearance of warts was observed in 18 patients (81.8%) of the intralesional group and 14 patients (63.3%) of the intramuscular group; however, the difference was not statistically significant. Adverse effects were transient and insignificant, and no recurrence was reported in either group. Small study sample and different dosing schedules. Bivalent HPV vaccine, particularly by intralesional...Continue Reading

Citations

Mar 3, 2020·The Journal of Dermatological Treatment·Kanchana LeerunyakulSuthinee Rutnin
May 21, 2020·Journal of Cosmetic Dermatology·Ahmad NofalMohamed M Fawzy
Nov 11, 2020·International Journal of STD & AIDS·Georgios TyrosElectra Nicolaidou
Jan 13, 2021·American Journal of Clinical Dermatology·Peter C Friedman
May 4, 2020·Journal of the American Academy of Dermatology·Ahmad NofalAhmed Said Abdelshafy
Oct 23, 2020·Pediatric Dermatology·Nathan M Johnson, Clay M Pickard
May 11, 2020·Journal of the American Academy of Dermatology·Ahmad NofalAyman Marei

Dec 4, 2020·Annales de dermatologie et de vénéréologie·E Sbidian

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