PMID: 8604887Apr 1, 1996Paper

Intralesional vinblastine for treating AIDS-associated Kaposi's sarcoma of the oropharynx and larynx

The Annals of Otology, Rhinology, and Laryngology
M FriedmanD D Caldarelli

Abstract

Kaposi's sarcoma (KS), the most frequent malignant neoplasm associated with acquired immunodeficiency syndrome, often involves the oropharynx and larynx. This study evaluated the efficacy of intralesional vinblastine sulfate injection in oropharyngeal and laryngeal KS. Twenty-four human immunodeficiency virus-positive patients with a total of 26 KS lesions were treated with injections of 0.1- or 0.2-mg/mL vinblastine sulfate solution. Subsequent injections were administered at 4- to 5-week intervals if necessary until the lesions resolved or stabilized. Complete regression was achieved in 16 lesions (62%), 20% to 50% reduction in 4 lesions (15%), and less than 20% reduction in 3 lesions (12%). Two lesions (8%) did not respond, and 1 (4%) grew despite the injections. Thirteen patients experienced no adverse effects. Eleven patients reported pain not relieved by acetaminophen; 5 of these 11 also had ulceration secondary to the injection. Both pain and ulceration were self-limiting. We conclude that vinblastine injection is a viable option for treatment of oropharyngeal and laryngeal KS lesions.

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Citations

Feb 24, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·N AngouridakisJ Daniilidis
Aug 28, 2004·Journal of Voice : Official Journal of the Voice Foundation·Joseph R WatsonRobert Thayer Sataloff
Jul 5, 2016·Case Reports in Otolaryngology·Ela A ServerErol R Bozkurt
Jul 1, 1997·The Annals of Otology, Rhinology, and Laryngology·N F SchiffS M Shapshay
Jul 11, 1998·The Annals of Otology, Rhinology, and Laryngology·P NicolaiA Ferlito
Sep 23, 2003·Transplantation·Chun-Hou LiaoJun Chun
Feb 23, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Erin ReidDeborah A Freedman-Cass
Jun 11, 1999·American Journal of Clinical Oncology·E L GressenB W Corn

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