Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports.

BMC Cancer
Georg SeifertAnja Borgmann

Abstract

Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen. As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated. All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma. Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.

References

Jul 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·M F GlynnK N Jeejeebhoy
Feb 1, 1980·Archives of Surgery·M R HurtubiseK B McCredie
Apr 21, 2005·Thrombosis and Haemostasis·Désiré Collen, H Roger Lijnen

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Citations

Mar 3, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sonia MuguetPierre Jean Souquet

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