PMID: 3762137Sep 1, 1986Paper

Intraluminal release of serotonin during the interdigestive migrating complex in the canine small intestine

The Journal of Surgical Research
A FerraraB M Jaffe

Abstract

Intraluminal release of serotonin (5-HT) was evaluated in relation to the interdigestive migrating complex (IMC) in the canine small intestine. Thirty-Vella loops (TVL) were constructed in the proximal jejunum of eight dogs. After recovery, the loops were continuously perfused with normal saline at 37 degrees C and changes in intraluminal pressure recorded. For each 10-min period, a motility index (MI) was calculated using computer-assisted planimetry and expressed in mm2/10 min. Serotonin contents in the effluent perfusates were measured by radioimmunoassay. A characteristic phasic motor activity was recognized in the TVL with periods of rest or minimal activity (MI = 406 +/- 45 mm2/10 min, Phase I) alternating with periods of vigorous activity (MI = 2082 +/- 134 mm2/10 min, Phases II and III). Serotonin was constantly found in the effluent perfusates in relatively high concentrations, but 5-HT levels did not vary significantly with intestinal activity; levels averaged 120 +/- 19 ng/ml during Phase I and 110 +/- 13 ng/ml during phases II and III. We conclude that intraluminal 5-HT plays no major role in the physiologic local regulation of the canine IMC in the small intestine.

References

Nov 1, 1976·Annals of Surgery·J M Kellum, B M Jaffe
Nov 1, 1978·Acta Physiologica Scandinavica·H AhlmanL M Nyhus
Jan 1, 1971·Journal of Pharmaceutical Sciences·M F TansyF J Hohenleitner
Mar 1, 1971·Journal of Pharmaceutical Sciences·F J HohenleitnerR H Golder
Jul 1, 1981·Acta Physiologica Scandinavica·H AhlmanG Pettersson

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Citations

Mar 1, 1987·Digestive Diseases and Sciences·A FerraraB M Jaffe
Sep 9, 2004·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Toshiyuki TanakaZen Itoh
Feb 23, 2019·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Taichi HoritaIchiro Sakata

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