PMID: 589560Dec 1, 1977

Intralymphatic BCG in the treatment of gynecologic malignancies: a phase I study

C E ManganJ J Mikuta


Thirteen patients with a variety of advanced gynecologic malignancies were administered BCG via the dorsal lymphatics of the lower extremity in addition to standard accepted forms of therapy. Prolonged febrile courses, lymphangitis and suppurative adenitis were observed along the lymphatic pathway of the injected lower limbs. There was no correlation between reaction to a standard anergy panel and survival. There was also no correlation between reaction to a standard anergy panel and the inflammatory response to intralymphatic BCG (ILP-BCG). There was, however, a positive correlation between the inflammatory response to ILP-BCG and survival. Intralymphatic administration of immunostimulants may conceivably be of value as ancillary therapy for use in gynecologic malignancy. However, complications of this approach to immunotherapy are significant and the method should not be used until complications are decreased.


Sep 1, 1975·Journal of the National Cancer Institute·C E ManganJ J Mikuta
Jul 1, 1975·Acta Radiologica: Diagnosis·W A Fuchs, G Seiler-Rosenberg
Jun 20, 1974·The New England Journal of Medicine·R C BastH J Rapp
Jun 27, 1974·The New England Journal of Medicine·R C BastH J Rapp
Jan 1, 1973·British Journal of Cancer·R W Baldwin, M V Pimm
Oct 18, 1973·The New England Journal of Medicine·F C SparksD L Morton
Aug 15, 1974·American Journal of Obstetrics and Gynecology·R C Knapp, E A Friedman
Mar 1, 1972·Annals of Internal Medicine·A Z BlumingG Kamya
Nov 1, 1971·Cancer·C J McPeak
Mar 15, 1963·American Journal of Obstetrics and Gynecology·G A HAHNG DODD
Jan 1, 1964·American Journal of Obstetrics and Gynecology·R A PATTILLOR F MATTINGLY
Jun 1, 1964·The British Journal of Radiology·P A DOLAN
Apr 16, 1955·British Medical Journal·J B KINMONTHR K HARPER

Related Concepts

BCG Vaccine
Genital Neoplasms, Female
Injections, Intralymphatic
Status Lymphaticus
Hypersensitivity Skin Testing

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.