PMID: 589560Dec 1, 1977

Intralymphatic BCG in the treatment of gynecologic malignancies: a phase I study

Cancer
C E ManganJ J Mikuta

Abstract

Thirteen patients with a variety of advanced gynecologic malignancies were administered BCG via the dorsal lymphatics of the lower extremity in addition to standard accepted forms of therapy. Prolonged febrile courses, lymphangitis and suppurative adenitis were observed along the lymphatic pathway of the injected lower limbs. There was no correlation between reaction to a standard anergy panel and survival. There was also no correlation between reaction to a standard anergy panel and the inflammatory response to intralymphatic BCG (ILP-BCG). There was, however, a positive correlation between the inflammatory response to ILP-BCG and survival. Intralymphatic administration of immunostimulants may conceivably be of value as ancillary therapy for use in gynecologic malignancy. However, complications of this approach to immunotherapy are significant and the method should not be used until complications are decreased.

References

Sep 1, 1975·Journal of the National Cancer Institute·C E ManganJ J Mikuta
Jul 1, 1975·Acta Radiologica: Diagnosis·W A Fuchs, G Seiler-Rosenberg
Jun 20, 1974·The New England Journal of Medicine·R C BastH J Rapp
Jun 27, 1974·The New England Journal of Medicine·R C BastH J Rapp
Jan 1, 1973·British Journal of Cancer·R W Baldwin, M V Pimm
Oct 18, 1973·The New England Journal of Medicine·F C SparksD L Morton
Aug 15, 1974·American Journal of Obstetrics and Gynecology·R C Knapp, E A Friedman
Mar 1, 1972·Annals of Internal Medicine·A Z BlumingG Kamya
Nov 1, 1971·Cancer·C J McPeak
Mar 15, 1963·American Journal of Obstetrics and Gynecology·G A HAHNG DODD
Jan 1, 1964·American Journal of Obstetrics and Gynecology·R A PATTILLOR F MATTINGLY
Jun 1, 1964·The British Journal of Radiology·P A DOLAN
Apr 16, 1955·British Medical Journal·J B KINMONTHR K HARPER

Related Concepts

BCG Vaccine
Fever
Genital Neoplasms, Female
Inflammation
Injections, Intralymphatic
Lymphangitis
Status Lymphaticus
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Ulcer

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