Intralymphatic immunotherapy improves grass pollen allergic rhinoconjunctivitis: A 3-year randomized placebo-controlled trial.

The Journal of Allergy and Clinical Immunology
Søren H SkaarupHans Jürgen Hoffmann

Abstract

Allergic rhinoconjunctivitis is a global health problem. Different allergen immunotherapy regimes are marketed but have low adherence because they are expensive, complex, and time-consuming. New allergen immunotherapy forms are needed. In a 3-year follow-up double-blind randomized placebo-controlled trial, we aimed to investigate the effect of intralymphatic allergen immunotherapy (ILIT). Patients with grass pollen rhinoconjunctivitis were treated with 3 ILIT injections and an ILIT booster 1 year later, 3 ILIT injections and a placebo booster, or 3 placebo injections and a placebo booster. Primary outcome was improvement in a combined symptom and medication score (cSMS). A novel evaluation tool with a linear regression model of cSMS and grass pollen counts was developed. Secondary outcomes were changes in grass specific immunoglobulins and skin and nasal provocation tests to grass pollen. A total of 36 patients were included. Log10-transformed cSMS was reduced by 0.30 (95% CI, 0.11-0.49; P = .002), equaling 48.5% (95% CI, 24.5%-62%), in the entire 3-year follow-up period, significant only in the first follow-up season but not in the second and third seasons. The regression model showed a 37% (P < .001) reduction in cSMS. The bo...Continue Reading

References

Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gabriela SentiThomas M Kündig
Oct 14, 2009·Current Opinion in Allergy and Clinical Immunology·Gianenrico SennaGiovanni Passalacqua
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Gabriela SentiThomas M Kündig
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Terese HylanderLars Olaf Cardell
May 9, 2013·The Journal of Allergy and Clinical Immunology·Menno A KielMaureen P M H Rutten-van Mölken
Sep 17, 2013·The Journal of Allergy and Clinical Immunology·Marianne WittenLars K Poulsen
Jan 21, 2014·The Journal of Allergy and Clinical Immunology·Thomas M KündigGabriela Senti
Jun 18, 2014·The Journal of Allergy and Clinical Immunology·Johannes Martin SchmidHans Jürgen Hoffmann
Dec 27, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Amber M PattersonElizabeth A Erwin
Jan 26, 2017·Allergy·H J HoffmannP Sørensen
Feb 8, 2018·The Journal of Allergy and Clinical Immunology·Jean-Pierre AllamEike Gunther Wüstenberg
Jun 17, 2018·The Journal of Allergy and Clinical Immunology·Laila HellkvistLars Olaf Cardell
Nov 6, 2018·International Archives of Allergy and Immunology·Gabriela SentiThomas M Kündig
Nov 28, 2019·The Journal of Allergy and Clinical Immunology·Jon R KonradsenMarianne van Hage

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Citations

Dec 29, 2020·Current Opinion in Allergy and Clinical Immunology·Oluwatoyin AkinfenwaRaffaela Campana
May 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Oliver PfaarStefan Schülke
Jul 1, 2021·Allergy and Asthma Proceedings·Michael T Werner, John V Bosso
Aug 14, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Wolfgang Pfützner

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