Intralymphatic immunotherapy of pollen-induced rhinoconjunctivitis: a double-blind placebo-controlled trial

Respiratory Research
Terese HylanderLars-Olaf Cardell

Abstract

Allergen-specific immunotherapy represents the only disease-modifying treatment for allergic diseases. We and others have previously demonstrated that intralymphatic immunotherapy (ILIT), a less time-consuming alternative to conventional subcutaneous immunotherapy (SCIT), is safe and effective. However, this has recently been disputed. The aim of this study was therefore to expand our previous trial, further assessing the safety and efficacy of ILIT. Thirty-six patients with pollen-induced rhinoconjunctivitis were randomised to receive three intralymphatic inguinal injections of active allergen (1000 SQ-U birch- or grass-pollen) or placebo. Clinical effects, safety and circulating immunological markers were assessed before, 4 weeks after treatment and at the end of the consecutive pollen season. No moderate or severe reactions were recorded following ILIT. Patients receiving active ILIT experienced a significant improvement in self-recorded seasonal allergic symptoms, as compared to placebo (p = 0.05). In a subgroup of these patients ("improved"), a reduction in nasal symptoms following nasal allergen provocation was also demonstrated. No changes in total IgE or IgG4 were found. However, the affinity of allergen specific IgG4 f...Continue Reading

References

Dec 24, 2002·Current Opinion in Immunology·Ross M KedlPhilippa Marrack
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Anthony J Frew
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Petra A Wachholz, Stephen R Durham
Oct 7, 2004·Current Allergy and Asthma Reports·Jay M PortnoyP Brock Williams
Sep 5, 2006·Expert Opinion on Drug Delivery·Melanie Werner-KleinKlaus J Erb
Feb 15, 2007·Allergy·J BousquetN Khaltaev
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gabriela SentiThomas M Kündig
Jun 28, 2011·Allergy·T M Kündig
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Gabriela SentiThomas M Kündig
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Terese HylanderLars Olaf Cardell
Sep 17, 2013·The Journal of Allergy and Clinical Immunology·Marianne WittenLars K Poulsen
Jan 21, 2014·The Journal of Allergy and Clinical Immunology·Thomas M KündigGabriela Senti
Mar 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Melina MakatsoriMoises A Calderon
Mar 27, 2015·Science Translational Medicine·Cezmi A Akdis, Mübeccel Akdis
May 30, 2015·The World Allergy Organization Journal·Cezmi A Akdis, Mübeccel Akdis
Oct 16, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Á HjálmsdóttirPål Johansen
Dec 27, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Amber M PattersonElizabeth A Erwin

❮ Previous
Next ❯

Citations

Jun 9, 2016·Expert Opinion on Biological Therapy·Olivia LarssonLars Olaf Cardell
Sep 14, 2016·Expert Opinion on Biological Therapy·Matteo FerrandoGiorgio Walter Canonica
Jan 26, 2017·Allergy·H J HoffmannP Sørensen
Feb 16, 2017·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Zieglmayer
Mar 16, 2017·Allergy, Asthma & Immunology Research·Sang Pyo LeeJoo Hyun Jung
Jan 27, 2017·American Journal of Rhinology & Allergy·Mitat AricigilCemal Cingi
Sep 6, 2018·Human Vaccines & Immunotherapeutics·Manish Ramesh, Merhunisa Karagic
Jan 25, 2019·Expert Opinion on Investigational Drugs·Enrico HefflerGiorgio Walter Canonica
Feb 17, 2018·Current Allergy and Asthma Reports·Pattraporn SatitsuksanoaMübeccel Akdis
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
May 22, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Montserrat Alvaro-LozanoMarta Vazquez-Ortiz
Sep 11, 2018·Current Opinion in Allergy and Clinical Immunology·Mark W TennAnne K Ellis
Jan 13, 2018·Veterinary Dermatology·Katrin TimmClaudia S Nett-Mettler
Aug 3, 2017·Asia Pacific Allergy·Seon Tae KimSang Pyo Lee
Jun 9, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lubnaa HossenbaccusAnne K Ellis
Jul 28, 2020·Frontiers in Immunology·Anna I JoubertMartin Himly
Aug 31, 2017·Human Vaccines & Immunotherapeutics·Yan SuTeri Heiland
Aug 22, 2017·Human Vaccines & Immunotherapeutics·Carlos GamazoJuan M Irache
May 6, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Dan WeinfeldLars-Olaf Cardell
Jul 18, 2020·The Journal of Allergy and Clinical Immunology·Søren Helbo SkaarupHans Jürgen Hoffmann
Mar 18, 2021·Expert Review of Clinical Immunology·Lubnaa Hossenbaccus, Anne K Ellis
Jul 1, 2021·Allergy and Asthma Proceedings·Michael T Werner, John V Bosso
Aug 14, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Wolfgang Pfützner
Aug 26, 2021·Clinical and Translational Allergy·Nor Rahimah AiniBaharudin Abdullah
Jul 10, 2020·Molecular Pharmaceutics·Akhilesh Kumar ShakyaHarvinder Singh Gill

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
ILIT
SCIT

Related Concepts

Related Feeds

CFTR Mutant Structural Therapy

Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.