Intramembranous ossification and endochondral ossification are impaired differently between glucocorticoid-induced osteoporosis and estrogen deficiency-induced osteoporosis

Scientific Reports
Hongyang ZhangLiu Yang

Abstract

A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether these two kinds of ossification are different between glucocorticoid-induced osteoporosis (GIOP) and estrogen deficiency-induced osteoporosis (EDOP) are poorly understood. In this study, we established two bone repair models that exhibited repair via IO or EO and compared the pathological progress of each under GIOP and EDOP. In the cortical drill-hole model, which is repaired through IO, osteogenic differentiation was more seriously impaired in EDOP at the early stage than in GIOP. In the periosteum scratch model, in which EO is replicated, chondrocyte hypertrophy progression was delayed in both GIOP and EDOP. The in vitro results were consistent with the in vivo results. Our study is the first to establish bone repair models in which IO and EO occur separately, and the results strongly describe the differences in bone repair between GIOP and EDOP.

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Citations

Aug 12, 2018·Scientific Reports·Aldo Fontes-PereiraWagner Coelho de Albuquerque Pereira
Sep 19, 2019·Brazilian Oral Research·Adriana Luisa Goncalves AlmeidaAdalberto Luiz Rosa
Sep 11, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takashi Taguchi, Mandi J Lopez
Nov 5, 2019·Frontiers in Immunology·Mubashir AhmadJan Tuckermann
Nov 2, 2019·Medical Hypotheses·Dong-Gyun Han, Dong-Jun Kim
May 9, 2021·Biochemical and Biophysical Research Communications·Aoi Ikedo, Yuuki Imai
Apr 29, 2021·Tissue Engineering. Part C, Methods·Yohei KumabeTakahiro Niikura
Jun 6, 2020·Journal of Proteome Research·Julian L KesslerS Michael Yu
Aug 12, 2019·ACS Biomaterials Science & Engineering·Yan-Lei FanXi-Qiao Feng

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Methods Mentioned

BETA
PCR
dissection
confocal microscopy
protein assay

Software Mentioned

Pro Plus
Image

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