Intramolecular decarboxylative coupling as the key step in copper-catalyzed domino reaction: facile access to 2-(1,3,4-oxadiazol-2-yl)aniline derivatives

Chemical Communications : Chem Comm
Cheng XuAn-Xin Wu

Abstract

A copper-catalyzed domino protocol for the synthesis of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives has been developed from simple and available isatins and hydrazides. This domino process integrated consecutive condensation, base-promoted ring-opening and the key copper-catalyzed decarboxylative coupling for intramolecular C-O bond formation.

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Citations

Sep 4, 2015·Organic & Biomolecular Chemistry·Xiang-Yuan FanYong-Ming Zhu
Apr 9, 2018·Current Opinion in Chemical Biology·Iain A Stepek, Jeffrey W Bode
Jul 15, 2021·The Journal of Organic Chemistry·Peng QianZhiyong Wang
Sep 22, 2020·The Journal of Organic Chemistry·Peng QianLiangquan Sheng

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