Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains

Frontiers in Molecular Biosciences
Miguel ArbesúMiquel Pons

Abstract

Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we discuss how intramolecular fuzzy interactions function in signaling complexes. Focussing on the Src family of kinases, we argue that the intrinsically disordered domains that are unique for each of the family members and display a clear fingerprint of long range interactions in Src, might have critical roles as functional sensor or effectors and mediate allosteric communication via fuzzy interactions.

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Citations

Apr 14, 2019·Biomolecules·Supriyo Bhattacharya, Xingcheng Lin
Mar 1, 2019·Biomolecules·Wenning Wang, Dongdong Wang
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Sep 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·San HadžiJurij Lah

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Methods Mentioned

BETA
NMR
chemical shift
X-ray

Software Mentioned

Farseer

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