Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex

Dalton Transactions : an International Journal of Inorganic Chemistry
Shanta DharAkhil R Chakravarty

Abstract

The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 +/- 0.4 h(-1) and a rate enhancement of 1.55 x 10(8).

Citations

Jan 1, 2009·Bioinorganic Chemistry and Applications·Wojciech SzczepanikMałgorzata Jezowska-Bojczuk
Dec 29, 2006·Chemistry & Biodiversity·Pulimamidi R ReddyKandibanda S Rao
Apr 21, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Yan AnZong-Wan Mao
Aug 27, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·S PoornimaM Kandaswamy
Oct 12, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sidhali U ParsekarManjuri Kumar
Aug 9, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Juan HeLiang-Nian Ji
Apr 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Dongdong LiShiping Yan
Feb 12, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Jin-Tao WangLiang-Nian Ji
Apr 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Sellamuthu AnbuBabu Varghese
Sep 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Megha S DeshpandeChristian Näther
Dec 22, 2010·Journal of Biological Engineering·Julie E NorvilleThomas F Knight
Mar 20, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sidhali U ParsekarManjuri Kumar
Jun 29, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Amit KumarChebrolu P Rao
Oct 7, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Basudev MaityAkhil R Chakravarty
Dec 18, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Mei-Jin LiGuo-Nan Chen
Jun 9, 2007·Inorganic Chemistry·Megha S DeshpandeAvinash S Kumbhar

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