Intramural coronary artery constrictor reactivity to thromboxane is higher in male than in female rats

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Szabolcs VarbiroBela Szekacs

Abstract

The prevalence of cardiovascular disorders is higher among men than in age-matched women. This is probably related, in part, to gender-dependent differences in coronary function including thromboxane-A(2) (TXA(2)) sensitivity. This question has been examined only on major, epicardial coronaries. The intramural small arteries directly responsible for supplying the myocardial arterioles with blood have been hardly accessible for investigation, owing to difficulties in their preparation. Vasoconstrictor TXA(2) excess generated by platelets and the vascular wall may play an important role in coronary ischemic events. In the present study we tested the vasoconstrictor reactivity of intramural coronary arteries to TXA(2). Secondary, intramural branches of the left anterior descendent coronary artery of Sprague-Dawley rats (diameter: 200 microm) were placed into a vessel chamber. TXA(2) vasoconstrictor reactivity was measured on the basis of pressure-diameter curves in normal Krebs-Ringer solution and after addition of TXA(2) receptor agonist. Vasoconstrictor response induced by TXA(2) agonist was twice as strong in males compared with females for the whole pressure range ( p < 0.001). A gender-dependent difference was demonstrated in...Continue Reading

References

Mar 1, 1996·Journal of Cardiovascular Pharmacology·J W Karanian, P W Ramwell
Mar 5, 1999·Clinical and Experimental Pharmacology & Physiology·V M MillerD A Barber
Oct 6, 2001·Journal of Cardiovascular Pharmacology·M SzekeresA Koller

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Citations

Oct 30, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yin Xia, Raouf A Khalil
Aug 28, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yukui MaRaouf A Khalil
May 25, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Levente SaraSzabolcs Varbiro
Jun 3, 2021·Current Issues in Molecular Biology·Zoltán FontányiSzabolcs Várbíró

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