Intramural injection of biodegradable microspheres as a local drug-delivery system to inhibit neointimal thickening in a rabbit model of balloon angioplasty

Journal of Cardiovascular Pharmacology
F ValéroM E Bertrand

Abstract

Restenosis remains the major limitation of coronary angioplasty. The objective of this study was to develop microspheres able to be delivered at the angioplasty site for long-term drug release and to test their effects in a model of balloon angioplasty. Polylactic-co-glycolide acid microspheres (5-10 microm in diameter) were prepared by using an oil-in-water emulsion-solvent evaporation method. In vitro experiments with hydrocortisone-loaded microspheres revealed a hydrocortisone release for 4 weeks. We studied the in vivo effect of injection of microspheres into the arterial wall of New Zealand White rabbits by using a perforated balloon. Deep penetration of microspheres in the arterial wall was documented immediately after angioplasty. Intimal hyperplasia was assessed in iliac arteries 4 weeks after angioplasty. The morphometric analysis was performed in four groups of animals; the first group was subjected only to conventional angioplasty (control, n = 10), whereas the other three groups after conventional angioplasty were received perforated balloon angioplasty with saline (n = 10), microspheres (n = 10), or hydrocortisone-loaded microspheres (n = 7). Intramural injection of saline did not induce greater intimal hyperplasia...Continue Reading

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Citations

May 10, 2001·Biotechnology and Bioengineering·J B DickersonD J Goetz
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·I FishbeinG Golomb
Aug 16, 2000·Vascular Medicine·D S Ettenson, E R Edelman
May 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·P J BrayT A McCaffrey
Sep 15, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·I FishbeinG Golomb
Feb 7, 2002·Cardiovascular Drug Reviews·J Chamberlain

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