PMID: 6170416Nov 15, 1981Paper

Intramural papilloma of the vagina: evidence of Müllerian histogenesis

Cancer
T M UlbrightF T Kraus

Abstract

A papillary tumor occurred in the posterior-superior vaginal wall of a 5-year-old girl who was free of recurrence one year following surgical excision. The light microscopic features included papillae lined by eosinophilic cells with uniform, bland nuclei, solid areas of identical cells, and scattered glandular lumina which contained mucopolysaccharides. Foci of eosinophilic hyaline globules were another distinctive feature. Electron microscopy of the tumor demonstrated features associated with müllerian neoplasms including projecting microvilli, whorls of perinuclear cytoplasmic microfilaments, conspicuous lysosomes, squamous metaplasia, complex cytoplasmic interdigitations, and pseudoinclusions of "cytoplasmic" collagen. Previously described "mesonephric papillomas" of the vagina and cervix are compared with the tumor of the authors' patient. The previously described tumors share some histologic and clinical features, although they were superficial rather than intramural proliferations. The authors conclude that the ultrastructure, location, and documented presence of müllerian structures in the vagina favor a müllerian origin for this vaginal tumor. A number of other vaginal tumors that occur in children and young women show...Continue Reading

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Citations

Jan 1, 1994·Archives of Gynecology and Obstetrics·J E Lüttges, M Lübke
May 18, 2005·Journal of Pediatric and Adolescent Gynecology·Debra S Heller
Dec 12, 2001·Histopathology·M CohenR Drut
Apr 8, 1999·Journal of Clinical Pathology·S P DobbsD Ireland
Apr 4, 1998·Journal of Pediatric and Adolescent Gynecology·Y R SmithE L Hinton
Mar 8, 2016·Journal of Pediatric and Adolescent Gynecology·Sarah K McQuillanYasmin L Jayasinghe
Aug 19, 2007·Diagnostic Cytopathology·Monica L HollowellLiron Pantanowitz
Jan 22, 2005·Gynecologic Oncology·Sang Eun LeeHyo Pyo Lee
Jul 1, 1993·Pediatric Pathology·S GögüsZ Akçören
Jul 23, 2005·Ultrastructural Pathology·Gary W MierauLuann Goin
Jul 28, 2019·Journal of Clinical Pathology·Juan ZouKaixuan Yang
Mar 20, 2010·Journal of Clinical Pathology·Seema KaushalDeepika Deka
May 16, 2017·Case Reports in Pathology·Akiko MatsuzakiNaoki Yoshimi
Oct 22, 2014·Pediatric Surgery International·Venkat YalamanchiliPaul Stockmann

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