Intramuscular aripiprazole : a review of its use in the management of agitation in schizophrenia and bipolar I disorder

CNS Drugs
Mark Sanford, Lesley J Scott

Abstract

An intramuscular formulation of the atypical antipsychotic aripiprazole (Abilify) has been developed and is approved in the EU for use in agitation and disturbed behaviour associated with schizophrenia. In the US, it is approved for the treatment of agitation associated with schizophrenia or bipolar I disorder (manic or mixed). In large, well designed trials, intramuscular aripiprazole was an effective and generally well tolerated treatment for agitation associated with schizophrenia, schizoaffective disorder, schizophreniform disorder or bipolar I disorder. Intramuscular aripiprazole was more effective than placebo in these patient populations and was noninferior to intramuscular haloperidol in those with agitation associated with schizophrenia and its related disorders. Aripiprazole is associated with a low risk for extrapyramidal symptoms (EPS), cardiac effects, hyperprolactinaemia, weight gain and other metabolic disturbances. Head-to-head trials comparing intramuscular aripiprazole with other intramuscular atypical antipsychotics are required before the relative position of each of these agents can be fully determined. In the meantime, intramuscular aripiprazole, with its favourable tolerability profile, is a valuable trea...Continue Reading

References

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Citations

Jul 20, 2004·Drugs·Tracy Swainston Harrison, Caroline M Perry
May 27, 2005·Drugs·John Battaglia
Jun 9, 2005·Expert Review of Neurotherapeutics·Warren A Kinghorn, Joseph P McEvoy
Sep 8, 2005·Psychosomatics·Neil B SandsonKelly L Cozza

Related Concepts

Metabolic Process, Cellular
Antipsychotic Effect
Atypical Antipsychotic [EPC]
Assay OF Haloperidol
Schizophrenia
Piperazines
Hyperprolactinemia
Extrapyramidal Sign
Aripiprazole
Bipolar Disorder

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