Intramuscular nerve damage in lacerated skeletal muscles may direct the inflammatory cytokine response during recovery

Journal of Cellular Biochemistry
Barry P PereiraDavid T Leong

Abstract

The expression of inflammatory cytokines and growth factors in surgically repaired lacerated muscles over a 12-week recovery phase was investigated. We hypothesized that these expression levels are influenced by both neural and muscular damage within lacerated muscles. Microarrays were confirmed with reverse transcription-polymerase chain reaction assays and histology of biopsies at the lesion of three simulated lacerated muscle models in 130 adult rats. The lacerated medial gastrocnemius with the main intramuscular nerve branch either cut (DN), crushed but leaving an intact nerve sheath (RN); or preserved intact (PN) were compared. At 4 weeks, DN had a higher number of interleukins up-regulated. DN and RN also had a set of Bmp genes significantly expressed between 2 and 8 weeks (P ≤ 0.05). By 12 weeks, DN had a poorer and slower myogenic recovery and greater fibrosis formation correlating with an up-regulation of the Tgf-β gene family. DN also showed poorer re-innervation with higher mRNA expression levels of nerve growth factor (Ngf) and brain-derived neurotrophin growth factor (Bdnf) over RN and PN. This study demonstrates that the inflammatory response over 12 weeks in lacerated muscles may be directed by the type of intram...Continue Reading

References

Sep 1, 1984·The Journal of Hand Surgery·W E GarrettJ L Goldner
Oct 1, 1996·Cytokine & Growth Factor Reviews·I HusmannD Barritault
Mar 23, 1999·Muscle & Nerve·H L KellerJ G Cannon
May 5, 1999·Journal of Anatomy·G Terenghi
Mar 4, 2000·The Journal of Bone and Joint Surgery. British Volume·J MenetreyJ Huard
Aug 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K KamiE Senba
Dec 18, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James A CarsonJames M Reecy
Aug 2, 2003·Journal of Anatomy·Maria HillG Goldspink
Nov 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sonnie P KirkJohn J Bass
Dec 4, 2003·Journal of the Peripheral Nervous System : JPNS·Tessa GordonJ Gordon Boyd
Mar 31, 2004·Muscle & Nerve·Aymeric Y T LimMichel Merle
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball
Apr 27, 2005·The American Journal of Sports Medicine·Tero A H JärvinenMarkku Järvinen
Sep 1, 2005·The Journal of Bone and Joint Surgery. British Volume·J F KraghT J Walters
Nov 18, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jane BattJim Woodgett
Dec 2, 2005·Muscle & Nerve·Aymeric Y T LimV Prem Kumar
Jan 20, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Barry P PereiraV Prem Kumar
Aug 1, 2006·Neurobiology of Disease·Z ZhouA Bornemann
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura PelosiAntonio Musarò
May 5, 2007·The Journal of Physiology·Gordon L WarrenPetia P Simeonova
Apr 10, 2008·Neurological Research·Bruce M Carlson
Aug 5, 2008·The Journal of Bone and Joint Surgery. American Volume·John C ElfarMichael J Zuscik
Feb 14, 2009·Pflügers Archiv : European journal of physiology·Richard J ZemanChristopher Cardozo
Jul 3, 2009·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·L Mu, I Sanders
Dec 31, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Barry P PereiraSaminathan S Nathan
Jan 1, 2010·Current Pharmaceutical Design·Stefano Ciciliot, Stefano Schiaffino
Nov 26, 2010·Molecular Endocrinology·Samantha GardnerPeter Rotwein
Mar 23, 2011·Acta Physiologica·T A WashingtonJ A Carson
Jun 8, 2011·BMC Cell Biology·Melanie FriedrichsAndrea Vortkamp

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Citations

Sep 10, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Jaqueline de Souza, Carmem Gottfried
Feb 13, 2016·Cell Death and Differentiation·C ScioratiP Rovere-Querini
Dec 21, 2019·Tissue Engineering. Part a·Benjamin T CoronaSarah M Greising
Oct 31, 2020·PloS One·Antigona UlndreajMichael G Fehlings

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