PMID: 8961304Nov 15, 1996Paper

Intramuscular nerve sprouting induced by CNTF is associated with increases in CGRP content in mouse motor nerve terminals

Neuroscience Letters
O TarabalJ E Esquerda

Abstract

It is known that motor nerve terminal sprouting induced by either nerve injury or muscle paralysis is associated with an increase in calcitonin gene-related peptide (CGRP) content in the soma of motoneurons and in motor endplates. In the present study, CGRP-like immunoreactivity (CGRP-LI) was determined in motor endplates of animals in which nerve terminal sprouting had been induced by exogenous application of ciliary neurotrophic factor (CNTF). After 18 days of CNTF treatment we observed a significant increase in CGRP-LI in motor endplates. The results indicate that CGRP is upregulated when motor nerve outgrowth is induced, even in the absence of muscle paralysis or nerve lesion.

References

Jan 1, 1989·Progress in Neurobiology·A Ishida-Yamamoto, M Tohyama
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D N Ishii
Oct 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B CsillikE Knyihár-Csillik

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Citations

May 30, 2001·Brain Research·D W ZochodneK A Sharkey
Jan 5, 2002·Journal of Physiology, Paris·Frédéric A MeunierJordi Molgó
Nov 20, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Clàudia CerveróJordi Calderó
May 17, 2011·Journal of Neuropathology and Experimental Neurology·Elisabet DachsJosep E Esquerda
Sep 5, 2002·The Journal of Comparative Neurology·David González-ForeroAngel M Pastor
Jul 7, 2007·The Journal of Comparative Neurology·Megan C WrightYoung-Jin Son
Jul 22, 2020·Journal of Cachexia, Sarcopenia and Muscle·Alba BlascoJordi Calderó

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