PMID: 6402201Feb 26, 1983Paper

Intramuscular on demand analgesia: double blind controlled trial of pethidine, buprenorphine, morphine, and meptazinol

British Medical Journal
M HarmerM D Vickers

Abstract

An on demand intramuscular analgesic system using the Cardiff Palliator was tested. Forty consenting patients were studied after cholecystectomy in a double blind trial using increments of buprenorphine (0.15 mg), meptazinol (50 mg), morphine (5 mg), and pethidine (50 mg). Most patients attained good levels of pain relief (mean analogue pain score 36.5), comparable to intravenous on demand analgesia. There were no technical complications. Significant differences were found between drugs in dizziness (pethidine produced the worst score) but not with other side effects. Buprenorphine produced longer lasting analgesia than meptazinol or pethidine and also gave the lowest pain scores. Patterns of analgesic consumption were the same as with intravenous on demand systems, but larger amounts of drug were generally used. Relative analgesic potencies derived from drug consumption rates were also consistent with those from intravenous on demand studies. An on demand intramuscular analgesic system offers a simple but effective means of relieving severe postoperative pain.

References

Apr 14, 1979·British Medical Journal·J J Church
Apr 28, 1979·British Medical Journal·E N Fry
Jun 9, 1979·British Medical Journal·H T Davenport, B M Wright
Nov 1, 1976·Anaesthesia·S I RevillM I Hogg
Aug 1, 1973·British Journal of Anaesthesia·M CroninJ E Utting
Aug 1, 1980·British Journal of Anaesthesia·H MikkelsenC D Krohn
Sep 1, 1981·British Journal of Anaesthesia·P J SlatteryM D Vickers
Oct 1, 1980·British Journal of Anaesthesia·H J McQuayR A Moore
Nov 1, 1980·Anaesthesia and Intensive Care·J M Gibbs, H D Johnson

❮ Previous
Next ❯

Citations

Feb 1, 1996·Journal of Clinical Anesthesia·K A Lehmann
Jan 1, 1997·Journal of Pain and Symptom Management·G LamacraftB P Cavalletto
Apr 1, 1997·International Journal of Obstetric Anesthesia·K S JamesE McGrady
Aug 1, 1991·Acta Anaesthesiologica Scandinavica·I TigerstedtP J Neuvonen
Jan 1, 1988·Journal of Pain and Symptom Management·G Barkas, M E Duafala
Mar 23, 2005·Journal of Pain and Symptom Management·Rolley E JohnsonRichard Payne
Nov 1, 1988·Anaesthesia and Intensive Care·H OwenK Rowley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.