Intramuscular vascular endothelial growth factor gene therapy: fact or fiction?

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Intramuscular vascular endothelial growth factor gene therapy: fact or fiction?

Abstract

References

Direct gene transfer into mouse muscle in vivo

Site-specific gene expression in vivo by direct gene transfer into the arterial wall

Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increased vascular permeability without alterations of embryonic pattern formation

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia

VEGF gene delivery to muscle: potential role for vasculogenesis in adults

Transatlantic Conference on Clinical Trial Guidelines in Peripheral Arterial Disease: clinical trial methodology. Basel PAD Clinical Trial Methodology Group

Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor

Quantitative (1)H magnetic resonance spectroscopy of myoglobin de- and reoxygenation in skeletal muscle: reproducibility and effects of location and disease

Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy

Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end-stage unreconstructible lower extremity ischemia: preliminary results of a phase I trial

Intramuscular vascular endothelial growth factor gene therapy in patients with chronic critical leg ischemia

Citations

Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents

Review on early technology assessments of nanotechnologies in oncology.

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