Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour

The Cochrane Database of Systematic Reviews
Olufemi T OladapoEdgardo Abalos

Abstract

There is a general agreement that oxytocin given either through the intramuscular or intravenous route is effective in reducing postpartum blood loss. However, it is unclear whether the subtle differences between the mode of action of these routes have any effect on maternal and infant outcomes. To determine the comparative effectiveness and safety of oxytocin administered intramuscularly or intravenously for prophylactic management of the third stage of labour after vaginal birth. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2011). Randomised trials comparing intramuscular with intravenous oxytocin for prophylactic management of the third stage of labour after vaginal birth. We excluded quasi-randomised trials. Two review authors planned to independently assess trials for inclusion, assess risk of bias and extract data. The search strategies identified no trials for consideration but we identified one ongoing study. There is no evidence from randomised trials to evaluate the comparative benefits and risks of intramuscular and intravenous oxytocin when given to prevent excessive blood loss after vaginal birth. Randomised trials with adequate design and sample sizes are needed to assess ...Continue Reading

References

Nov 1, 1970·American Journal of Obstetrics and Gynecology·C H Hendricks, W E Brenner
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
May 5, 2000·The Cochrane Database of Systematic Reviews·W J PrendivilleS McDonald
Jul 25, 2000·The Cochrane Database of Systematic Reviews·W J PrendivilleS McDonald
Nov 1, 2001·The Cochrane Database of Systematic Reviews·D R ElbourneS McDonald
Jul 12, 2002·Anaesthesia·A Spence
Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·D O Selo-Ojeme
Sep 27, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·V D TsuA Widjaya
Aug 24, 2004·International Journal of Obstetric Anesthesia·A J PinderR Johnson
Oct 8, 2004·Clinical Pharmacology and Therapeutics·Beny CharbitJean Marty
Dec 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J V Lazarus, A Lalonde
Feb 18, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Roland T StrandStaffan Bergström
Dec 14, 2005·Statistics in Medicine·Roger M HarbordJonathan A C Sterne
Apr 4, 2006·Lancet·Khalid S KhanPaul Fa Van Look
Jan 1, 1909·The Biochemical Journal·H H Dale
Sep 30, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Guillermo CarroliA Metin Gulmezoglu
Jun 9, 2009·British Journal of Anaesthesia·E LangesaeterA Stubhaug
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Hora SoltaniThomas A Poulose

❮ Previous
Next ❯

Citations

Feb 26, 2013·BMC Pregnancy and Childbirth·Wendy R SheldonJames Trussell
Nov 28, 2013·The Cochrane Database of Systematic Reviews·Yukari YajuRintaro Mori
Apr 15, 2016·The Cochrane Database of Systematic Reviews·Tomas PantojaValentina P Serrano
Sep 25, 2018·The Cochrane Database of Systematic Reviews·Olufemi T OladapoEdgardo Abalos
Jun 5, 2014·Journal of Perinatal Medicine·Ulaş FidanAli Ergün
Nov 11, 2020·The Cochrane Database of Systematic Reviews·Olufemi T OladapoArgyro Papadopoulou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
A Metin GülmezogluG Hofmeyr
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
H Abdel-AleemG Hofmeyr
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Fernando AlthabePierre Buekens
The Cochrane Database of Systematic Reviews
Cecily M BegleyWilliam McGuire
© 2022 Meta ULC. All rights reserved