Intramyocardial bone marrow mononuclear cell transplantation in ischemic heart failure: Long-term follow-up

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Miia LehtinenHelsinki BMMC Collaboration

Abstract

Long-term results regarding treatment of chronic ischemic heart failure with bone marrow mononuclear cells (BMMCs) have been few. We received encouraging results at the 1-year follow-up of patients treated with combined coronary artery bypass grafting (CABG) and BMMCs, so we decided to extend the follow-up. The study patients had received injections of BMMCs or vehicle into the myocardial infarction border area during CABG in a randomized and double-blind manner. We could contact 36 of the 39 patients recruited for the original study. Pre-operatively and after an extended follow-up period, we performed magnetic resonance imaging, measured pro-B-type amino-terminal natriuretic peptide, reviewed patient records from the follow-up period, and determined current quality of life with the Medical Outcomes Study Short-Form 36 (SF-36) Health Survey. The median follow-up time was 60.7 months (interquartile range [IQR], 45.1-72.6 months). No statistically significant difference was detected in change of pro-B-type amino-terminal natriuretic peptide values or in quality of life between groups. The median change in left ventricular ejection fraction was 4.9% (IQR, -2.1% to 12.3%) for controls and 3.9% (IQR, -5.2% to 10.2%) for the BMMC gro...Continue Reading

Associated Clinical Trials

References

Feb 24, 2010·Nature Reviews. Cardiology·Kai C Wollert, Helmut Drexler
Jun 26, 2010·European Journal of Heart Failure·Bodo-Eckehard StrauerChristiana M Schannwell
Nov 27, 2010·Cardiovascular Therapeutics·Jennifer L Hellawell, Kenneth B Margulies
Mar 14, 2014·JACC. Heart Failure·Eugene Braunwald
Mar 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tommi PätiläAri Harjula
Apr 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jacob Joseph

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Citations

Dec 25, 2016·The Cochrane Database of Systematic Reviews·Sheila A FisherEnca Martin-Rendon
Jan 13, 2018·World Journal of Stem Cells·Maria DorobantuMiruna Mihaela Micheu

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