Intramyocardial haemorrhage and prognosis after ST-elevation myocardial infarction

European Heart Journal Cardiovascular Imaging
Sebastian Johannes ReinstadlerIngo Eitel

Abstract

To evaluate the prognostic value of intramyocardial haemorrhage (IMH) depicted by T2* imaging for risk stratification in ST-elevation myocardial infarction (STEMI) patients in comparison with established cardiac magnetic resonance (CMR) prognosis markers. This multicentre study enrolled 264 patients reperfused within 12 h after symptom onset. CMR was performed within the first week after STEMI to assess left ventricular function and infarct characteristics including IMH. The primary endpoint was a composite of death, reinfarction, and new congestive heart failure (major adverse cardiac events, MACE) at 12 months. MACE occurred in 19 patients (7.2%) showing a higher prevalence of IMH when compared with patients without MACE (47% vs. 21%, P = 0.008). The presence of IMH (n = 60, 23%) was independently associated with MACE after adjusting for clinical risk factors [hazard ratio 2.7, 95% confidence intervals (CIs) 1.1-6.6; P = 0.032] or other CMR prognosis markers (hazard ratio 3.1, 95% CI 1.2-7.7; P = 0.013). The addition of IMH to a model of prognostic CMR parameters (ejection fraction, infarct size, and microvascular obstruction) led to net reclassification improvement of 0.42 (95% CI 0.11-0.73, P = 0.009). IMH assessed by T2* i...Continue Reading

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Citations

Jul 4, 2019·Circulation Research·Giampaolo NiccoliIngo Eitel
Jul 22, 2019·European Heart Journal Cardiovascular Imaging·Pier Giorgio MasciJan Bogaert
Aug 8, 2019·Journal of the American Heart Association·Thomas StiermaierAndreas Schuster
Sep 17, 2020·La Radiologia medica·Vitaliano Buffa, Paolo Di Renzi
Apr 11, 2020·Journal of Clinical Medicine·Martin ReindlSebastian Johannes Reinstadler
Feb 17, 2019·The International Journal of Cardiovascular Imaging·Hans-Josef FeistritzerHolger Thiele
Oct 17, 2019·Basic Research in Cardiology·Gerd Heusch
Dec 16, 2020·ESC Heart Failure·Dominik JenčaPeter Wohlfahrt
Jan 15, 2021·The International Journal of Cardiovascular Imaging·Maria Ferré-VallverdúBegoña Igual-Muñoz
Nov 23, 2020·Heart Failure Clinics·Aneesh S Dhore-Patil, Ashish Aneja
Apr 23, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Magdalena HolzknechtAgnes Mayr
Oct 17, 2020·Cardiovascular Research·Xuekun WuKai C Wollert
Jun 1, 2021·Frontiers in Neuroscience·Athanasios LourbopoulosConstantinos Pantos
May 24, 2021·JACC. Cardiovascular Imaging·Martin ReindlSebastian J Reinstadler
Jun 21, 2021·International Journal of Cardiology·Magdalena HolzknechtSebastian Johannes Reinstadler
Nov 10, 2021·European Heart Journal. Acute Cardiovascular Care·Johannes P SchwaigerGert Klug
Dec 2, 2021·European Heart Journal. Acute Cardiovascular Care·Christina TillerSebastian J Reinstadler
Sep 16, 2021·Journal of Thoracic Imaging·Giuseppe MuscogiuriGianluca Pontone
Jan 14, 2022·Basic Research in Cardiology·Gerd Heusch

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