Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of the MESAMI 1 pilot trial

International Journal of Cardiology
D GuijarroJ Roncalli

Abstract

The MESAMI 1 trial was a bicentric pilot study designed to test the feasibility and safety of intramyocardially injected autologous bone marrow-derived mesenchymal stromal cells (MSCs) for the treatment of ischemic cardiomyopathy. The study included 10 patients with chronic myocardial ischemia, left ventricular (LV) ejection fractions (EFs) of ≤35%, and reversible perfusion defects who were on stable optimal medical therapy and were not candidates for revascularization. MSCs (mean: 61.5×10(6) cells per patient) were injected into 10-16 viable sites at the border of the LV scar via a NOGA-guided catheter. Both primary endpoints, feasibility (successful harvest, expansion, and injection of autologous MSCs) and safety (absence of severe adverse events [SAEs]) were met in all 10 patients at the 1-month follow-up time point, and none of the SAEs reported during the full 2-year follow-up period were attributable to the study intervention. The results of secondary efficacy endpoint analyses identified significant improvements from baseline to Month 12 in LVEF (29.4±2.0% versus 35.7±2.5%; p=0.003), LV end-systolic volume (167.8±18.8mL versus 156.1±28.6mL; p=0.04), 6-min walk test and NYHA functional class. Our results suggest that auto...Continue Reading

Associated Clinical Trials

References

Mar 1, 1981·British Heart Journal·R A GreenbaumR H Anderson
Sep 19, 1997·Journal of Computer Assisted Tomography·R J van der GeestJ H Reiber
Jun 25, 2002·The Annals of Thoracic Surgery·Jay G ShakeBradley J Martin
May 21, 2009·JAMA : the Journal of the American Medical Association·Jan van RamshorstDouwe E Atsma
Mar 18, 2010·Circulation. Cardiovascular Imaging·Julien NahumPascal Lim
Apr 17, 2010·JACC. Cardiovascular Imaging·Jun Koyama, Rodney H Falk
Sep 24, 2011·Journal of the American College of Cardiology·John Gorcsan, Hidekazu Tanaka
Jun 12, 2013·Stem Cell Research & Therapy·Luc SensebéSandrine Fleury-Cappellesso
Jun 24, 2014·American Heart Journal·Emerson C PerinFrancisco Fernández-Avilés

❮ Previous
Next ❯

Citations

Jun 25, 2016·International Journal of Molecular Sciences·Shan LiuYuanyuan Zhang
Aug 10, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuya Kobayashi, Ken Suzuki
Mar 15, 2018·Stem Cells International·Heiko LemckeRobert David
May 27, 2020·Journal of Cellular Physiology·Shirin TavakoliAdel Naimi
Oct 20, 2018·International Journal of Molecular Sciences·Andrea GhiroldiLuigi Anastasia
May 21, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YagyuHisao Ogawa
Aug 5, 2017·Frontiers in Cardiovascular Medicine·Yin Yee LeongJun Jie Tan
Mar 3, 2020·Frontiers in Veterinary Science·Suryo KuncorojaktiChenphop Sawangmake
Sep 23, 2016·Transplantation·Ignacio Anegon, Tuan Huy Nguyen
May 21, 2020·Frontiers in Cell and Developmental Biology·Ling SunFengxiang Zhang
Jul 12, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Amish N Raval, Carl J Pepine
Feb 13, 2021·Frontiers in Cardiovascular Medicine·Weili ShiKeji Chen
Feb 4, 2021·International Journal of Molecular Sciences·Hsuan PengAhmed Abdel-Latif
Feb 8, 2020·Cardiology in Review·Joseph Rudman, William H Frishman
May 3, 2020·Current Stem Cell Research & Therapy·Saeideh Gholamzadeh KhoeiMohsen Sheykhhasan
Apr 20, 2021·Cardiovascular Research·Roberto BolliArunpreet Kahlon
Jun 12, 2021·Medicinal Research Reviews·Hanne BeliënAnnelies Bronckaers
Jun 25, 2021·Stem Cell Research & Therapy·Iman Razeghian-JahromiJerome Roncalli
Jul 25, 2021·International Journal of Molecular Sciences·Fernanda GubertGisele Zapata-Sudo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.