Intranasal administration of IGF-I improves behavior and Purkinje cell pathology in SCA1 mice

Brain Research Bulletin
Parminder J S VigMaripar E Lopez

Abstract

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by the expansion of polyglutamine repeat within ataxin-1 protein. Cerebellar Purkinje cells are the primary targets of SCA1 pathology. These cells synthesize insulin-like growth factor-I (IGF-I) and express its receptors during their entire life. The aim of present study was to determine if intranasally administered IGF-I to SCA1 transgenic mice suppresses toxic effects of ataxin-1. Two-week old SCA1 heterozygous animals were randomly divided into two treatment groups of IGF-I (30 and 60 microg IGF-I/animal) and a vehicle-treated control group. The wildtype animals served as normal controls. IGF-I or vehicle was administered at 48 h intervals for the total of 10 doses. Animals were then subjected to rotarod test, sacrificed, brains removed and processed for immunohistochemical and Western blot analysis. Radiolabeled IGF-I and bioactive TAT peptide accumulated in the brains of SCA1 mice following intranasal administration validating the use of intranasal route. SCA1 mice showed SCA1 pathology with impaired motor function and downregulation of calcium binding proteins as compared to wildtype mice. However, 30 and 60 microg IGF-I-treated animals showed impr...Continue Reading

References

Feb 1, 1988·Acta Physiologica Scandinavica·I K AnderssonH A Hansson
Oct 15, 1995·Journal of Neuroscience Research·M P Nieto-BonaI Torres-Aleman
Mar 1, 1996·Annals of Neurology·I Torres-AlemanJ Berciano
Feb 20, 1997·Brain Research. Developmental Brain Research·W ZhangW H Lee
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S DoréR Quirion
Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M P Nieto-BonaI Torres-Alemán
Sep 11, 2001·The American Journal of Pathology·P J SkinnerH T Orr
Jun 6, 2003·The European Journal of Neuroscience·Yuko FukudomeMasanobu Kano
Nov 5, 2003·Medicinal Research Reviews·Ming Zhao, Ralph Weissleder
Feb 22, 2005·Advanced Drug Delivery Reviews·Hilary BrooksEric Vivès
Jun 7, 2005·British Journal of Pharmacology·Simon W JonesMark A Lindsay
Jun 14, 2005·Brain Research. Brain Research Reviews·A M FernandezI Torres-Aleman

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Citations

Nov 28, 2013·Behavioural Brain Research·Daria CameraPhilip Poronnik
Dec 19, 2013·Molecular Neurobiology·Carla LopesA Cristina Rego
Oct 23, 2014·International Journal of Molecular Sciences·Lucía Calatrava-FerrerasEulalia Bazán
Nov 13, 2013·Expert Opinion on Drug Delivery·Suzanne M de la Monte
May 6, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Isabel SchultzLorenz Meinel
Apr 21, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Jonas Alex Morales SauteLaura Bannach Jardim
Nov 15, 2012·Stem Cells International·Lucía Calatrava-FerrerasEulalia Bazán
Jan 5, 2010·Bioscience Hypotheses·Parminder J S VigMaripar E Lopez
Jun 7, 2014·Journal of Neurochemistry·Scoty M HearstParminder J S Vig
May 12, 2019·GeroScience·Gabriela E Farias QuipildorDerek M Huffman
Jan 1, 2014·Cerebellum & Ataxias·Irene Sanz-GallegoJavier Arpa
Jan 1, 2014·Cerebellum & Ataxias·Irene Sanz-GallegoJavier Arpa

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