Intranasal air sampling in homes: relationships among reservoir allergen concentrations and asthma severity

The Journal of Allergy and Clinical Immunology
Robin B GoreAdnan Custovic

Abstract

The relationship among inhaled allergen exposure, sensitization, and asthma severity is unknown. To investigate the relationship among personal allergen exposure, reservoir dust allergen concentrations, and physiological measures of asthma severity; to examine the numbers of particles inspired that react with autologous IgE and IgG4. A total of 117 patients with asthma wore 5 nasal air samplers (NASs) at home: 1 each for exposure to mite, cat and dog allergens, NAS-IgE, and NAS-IgG4. NASs were processed by HALOgen assay for allergen measurement and incubated with autologous serum for detection of NAS-IgE and NAS-IgG4. Reservoir allergen concentrations were measured by ELISA. Subjects' asthma severity was ascertained by measurement of lung function, exhaled nitric oxide, and nonspecific bronchial reactivity to histamine. Nasal air sampler counts correlated with reservoir concentrations for cat (r=0.31; P=.001) and dog (r=0.20; P=.03) but not mite allergen (r=0.001; P=1.0). There was no significant relationship between sensitization with exposure measured by NAS to any allergen and PD20FEV1 (F[3,60]=1.60; P=.20); however, sensitization with exposure in dust reservoirs had significant effects on PD20FEV1 for any allergen (F[3,59]=...Continue Reading

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Citations

Jul 3, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Richard W Weber
Oct 31, 2009·Current Opinion in Pulmonary Medicine·Robin B Gore
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Jul 8, 2008·The Journal of Allergy and Clinical Immunology·Euan R ToveyGuy B Marks
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Aug 2, 2019·Expert Review of Respiratory Medicine·Adnan CustovicAngela Simpson
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Apr 14, 2021·Environmental Research·Chiara SuannoStefano Del Duca
Jun 22, 2021·Journal of Environmental Health Science & Engineering·Zhu ChengBaizhan Li

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