Intranasal atrial natriuretic peptide acts as central nervous inhibitor of the hypothalamo-pituitary-adrenal stress system in humans

The Journal of Clinical Endocrinology and Metabolism
Boris PerrasHorst L Fehm

Abstract

Increased hypothalamo-pituitary-adrenal activity contributes to morbidity in widespread metabolic and psychiatric diseases. Inhibition of hypercortisolism represents a promising therapeutic strategy in these conditions, which currently cannot be used. Here, we tested the hypothesis that atrial natriuretic peptide (ANP) administered intranasally is a safe and feasible inhibitor of pituitary-adrenal activity at the central nervous level. Thirty minutes after intranasal administration of ANP (1 mg) and placebo, pituitary-adrenal activity was stimulated in 18 healthy men by two tests: 1) a standard insulin-hypoglycemia test and 2) CRH combined with vasopressin (VP), respectively. ACTH, cortisol, VP, blood pressure, heart rate, and measures of fluid balance were also recorded. Pretreatment with ANP suppressed cortisol (P < 0.01) and ACTH (P < 0.05) secretory responses to insulin-induced hypoglycemia to about half of that seen after placebo, but pituitary-adrenal activity was not suppressed by CRH/VP injection (P > 0.7). Indicators of fluid balance, cardiovascular parameters, and self-report measures were not influenced by the treatment. Results indicate a strong inhibition of stimulated pituitary-adrenal activity after intranasal ad...Continue Reading

Citations

Sep 4, 2013·European Heart Journal·Piotr Ponikowski, Ewa A Jankowska
Apr 18, 2006·Journal of Physiological Anthropology·James A Stewart
Jul 21, 2009·Epilepsy Research·Markus RauchenzaunerKevin Rostasy
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Suhayla Mukaddam-Daher
May 28, 2016·Neuroscience and Biobehavioral Reviews·Simin MahinradBehnam Sabayan
Dec 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Aldo ClericoMichele Emdin

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