Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ying-Zheng ZhaoHo Lun Wong

Abstract

Basic fibroblast growth factor (bFGF) may protect stroke patients from cerebral ischemia-reperfusion (I/R) injury. In this study, we report the intranasal use of novel nanoliposomes for the brain delivery of bFGF in a rat model of cerebral I/R. Compared with free bFGF, nanoliposomal therapy was able to significantly improve bFGF accumulation in brain tissues (p<0.05) including the most affected ischemic penumbra regions (e.g. hippocampus, pallium). After intranasal bFGF-nanoliposomal treatment for 3 consecutive days, functional recovery as indicated by improved neurologic deficit score and spontaneous locomotor activity was observed, and the stroke infarct volume was nearly halved (p<0.001) which persisted after 21days. These neuroprotective effects could be blocked by the PI3-K/Akt inhibitor LY294002, indicating the involvement of PI3-K/Akt activation in the therapeutic action. Overall, our results support the intranasal use of nanoliposomal bFGF as an efficient, non-invasive means to bypass the blood-brain barrier for ischemic stroke treatment.

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M FisherS P Finklestein
Feb 21, 1997·Cell·T F FrankeL C Cantley
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YanoY Ushio
Aug 25, 2001·Annual Review of Neuroscience·M V SofroniewW C Mobley
Mar 6, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisbeth Illum
Aug 27, 2003·Journal of Pharmacological Sciences·Kohji Fukunaga, Takayuki Kawano
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Kuniyasu WadaSeth P Finklestein
Jul 21, 2004·Cell·Louis F Reichardt, William C Mobley
Apr 29, 2005·Current Drug Targets. CNS and Neurological Disorders·Jing Mei Ren, Seth P Finklestein
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 14, 2006·Current Drug Delivery·Sandip B Tiwari, Mansoor M Amiji
Jul 20, 2006·Current Drug Delivery·Rubiana Mara MainardesMaria Palmira Daflon Gremião
Nov 24, 2006·Stroke; a Journal of Cerebral Circulation·Ronen R LekerRonald D G McKay
May 4, 2007·International Journal of Pharmaceutics·Henry R CostantinoSteven C Quay
Jul 14, 2007·Neuro-degenerative Diseases·K K Jain
Sep 4, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Harris Pratsinis, Dimitris Kletsas
Mar 1, 2008·Neuropharmacology·Kristian P DoyleMary P Stenzel-Poore
Mar 18, 2009·Journal of Neural Transmission·G MudòNatale Belluardo
Apr 28, 2009·Advanced Drug Delivery Reviews·Hyun Ah KimMinhyung Lee
Jun 27, 2009·International Journal of Pharmaceutics·Alpesh MistryLisbeth Illum
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 1, 2008·Indian Journal of Pharmaceutical Sciences·R C DoijadN V Deshmukh
Jun 3, 2010·Drug Development and Industrial Pharmacy·Ji-Lai TianYing Zhang
Oct 14, 2010·Journal of Biochemistry·Nobuyuki Itoh, David M Ornitz
Oct 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stefania ChrissouliDimitris Kletsas
Mar 8, 2011·Burns : Journal of the International Society for Burn Injuries·Qi XiangXiaokun Li
Sep 13, 2011·Journal of Experimental Stroke & Translational Medicine·Shimin LiuH Richard Winn
Nov 29, 2011·Advanced Drug Delivery Reviews·Jeffrey J Lochhead, Robert G Thorne
Feb 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danica Petrovic-DjergovicDavid J Pinsky
Oct 10, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sophia L B OliveiraHenning Ulrich
Nov 3, 2012·Current Pharmaceutical Design·Seyed Khosrow TayebatiFrancesco Amenta
Jan 12, 2013·Pharmaceutical Research·Taiyoun RhimMinhyung Lee
Feb 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiang YunMark S Kindy
Apr 3, 2014·Advanced Healthcare Materials·Stuart Kyle, Sikha Saha

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Citations

Jul 26, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Abderahim GacebGesine Paul
Jul 6, 2019·Journal of Neuroendocrinology·Ruirui DongShigong Zhu
Jul 22, 2018·Frontiers in Neuroscience·Lorena F FernandesFrédéric Frézard
Dec 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hamed AmaniOmid Akhavan
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kun ZhangFangxia Guan
Oct 18, 2020·International Journal of Molecular Sciences·Xinyue DongZhenjia Wang
Jan 7, 2021·Expert Opinion on Drug Delivery·Andrea PerrelliSaverio Francesco Retta
Jan 5, 2021·Frontiers in Neuroscience·Hui WangAi-Min Wu
Apr 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raghavendra UpadhyaAshok K Shetty
Sep 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dezhuang YeHong Chen
Jul 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dezhuang YeHong Chen
Jul 20, 2019·Brain Research Bulletin·Gisele E BruchAndré R Massensini
Aug 15, 2021·International Journal of Pharmaceutics·Flavia Laffleur, Bettina Bauer
Nov 4, 2021·Drug Delivery and Translational Research·Mireya L Borrajo, María José Alonso
Nov 21, 2021·Neurochemical Research·Thuy Trang NguyenGiau Van Vo

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