Intranasal Drug Delivery: A Non-Invasive Approach for the Better Delivery of Neurotherapeutics

Pharmaceutical Nanotechnology
Hitesh KumarUmesh Gupta

Abstract

The convoluted pathophysiology of brain disorders along with penetration issue of drugs to brain represents major hurdle that requires some novel therapies. The blood-brain barrier (BBB) denotes a rigid barrier for delivery of therapeutics in vivo; to overcome this barrier, intranasal delivery is an excellent strategy to deliver the drug directly to brain via olfactory and trigeminal nerve pathways that originate as olfactory neuro-epithelium in the nasal cavity and terminate in brain. Kind of therapeutics like low molecular weight drugs can be delivered to the CNS via this route. In this review, we have outlined the anatomy and physiological aspect of nasal mucosa, certain hurdles, various strategies including importance of muco-adhesive polymers to increase the drug delivery and possible clinical prospects that partly contribute in intranasal drug delivery. Exhaustive literature survey related to intranasal drug delivery system revealed the new strategy that circumvents the BBB, based on non-invasive concept for treating various CNS disorders. Numerous advantages like prompt effects, self-medication through wide-ranging devices, and the frequent as well protracted dosing are associated with this novel route. Recently few repo...Continue Reading

Citations

May 22, 2020·Frontiers in Cell and Developmental Biology·Beatrice SalvatoriMariangela Morlando
Jan 5, 2022·Naunyn-Schmiedeberg's Archives of Pharmacology·Fatemeh Moradi, Nasrin Dashti

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