Abstract
Allergen specific nasal challenge (ASNC) is an optimal method to study the pathophysiological mechanisms sustaining the allergic inflammation and in particular the adhesion molecule system, which is involved in cellular infiltration of nasal mucosa. Topical steroids have been accepted as a highly effective anti-inflammatory therapy for allergic rhinitis. The aim of this double-blind placebo- controlled study was the evaluation of clinical and cytological parameters, including ICAM-1 expression on nasal epithelial cells, after a 4 week treatment with nasal fluticasone propionate (200 microg/daily) or placebo, using the model of ASNC. Twenty allergic rhinitics underwent nasal challenge before and after treatment. The following parameters were evaluated: (i) nasal symptoms (rhinorrhoea, itching, sneezing, obstruction), (ii) inflammatory cells (eosinophils and neutrophils), (iii) ICAM-1 expression on nasal epithelial cells at baseline, 30 min (early phase) and 6 h (late phase) after ASNC. Fluticasone propionate was capable of reducing: (i) clinical symptoms during both early (P<0.001) and late phase (P<0.04), (ii) eosinophil (P<0.002) and neutrophil (P<0.001) infiltrate during late phase, and (iii) ICAM-1 expression on nasal epithe...Continue Reading
References
Nov 1, 1992·The Journal of Allergy and Clinical Immunology·E Calderón, R F Lockey
May 1, 1992·The Journal of Allergy and Clinical Immunology·S LozewiczR J Davies
Mar 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C SvenssonC G Persson
Nov 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H KlementssonC G Persson
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Feb 1, 1994·Drugs·S M HollidayE M Sorkin
Mar 1, 1994·Allergy·G W CanonicaM Bagnasco
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·G CiprandiG W Canonica
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R M NaclerioL M Lichtenstein
Jan 1, 1995·Allergy·M Johnson
Jan 1, 1995·Allergy·T GodthelpW J Fokkens
Jan 1, 1995·Allergy·W W Storms
Jan 1, 1995·Allergy·P H Howarth
Oct 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S RakS R Durham
Oct 1, 1994·The Journal of Allergy and Clinical Immunology·G CiprandiG W Canonica
Mar 1, 1993·The Journal of Allergy and Clinical Immunology·G CiprandiG W Canonica
Oct 1, 1993·The Journal of Allergy and Clinical Immunology·L C AltmanD L Luchtel
Oct 1, 1993·Allergy·N Mygind
Jan 1, 1993·European Journal of Clinical Pharmacology·G CiprandiG W Canonica
May 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Mygind, R Dahl
May 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Mygind, R Dahl
Sep 23, 1997·Allergy·F PaolieriG W Canonica
Jan 19, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F PaolieriM Bagnasco
Citations
Jul 25, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maria Angela ToscaGiorgio Ciprandi
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I HussainD L Hamilos
Feb 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M ContoliA Papi
Jun 16, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H ShirasakiT Himi
Sep 22, 2009·Clinical and Experimental Immunology·G W Canonica, E Compalati
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Di LorenzoC Caruso
Apr 25, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Leif BjermerMagnus C Wickman
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization