Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge

European Journal of Immunology
Nathalie EtchartSam Hou

Abstract

We have previously shown that following intranasal exposure to influenza virus, specific plasma cells are generated in the nasal-associated lymphoid tissue (NALT) and maintained for the life of the animal. However, we also showed that following infection with respiratory syncytial virus (RSV), specific plasma cells are generated in the NALT but wane quickly and are not maintained even after challenge, even though RSV-specific serum antibody responses remain robust. Only infection with influenza virus generated sterilising immunity, implying a role for these long-lived plasma cells in protection. We show here that the RSV-specific IgA NALT plasma cell population and lung antibody levels can be substantially boosted, both at acute and memory time points, by intranasal immunisation with inactivated RSV (iRSV) in combination with bacterial outer membrane vesicles (OMV) compared to live RSV alone. Finally, challenge with live RSV showed that immunisation with iRSV and OMV protect against both virus replication in the lung and the eosinophil infiltrate generated by either live RSV or iRSV alone. These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protecti...Continue Reading

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Citations

Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Susan M BuenoAlexis M Kalergis
Feb 18, 2011·Clinical and Vaccine Immunology : CVI·Stefan FernandezRobert G Ulrich
Feb 26, 2008·Vaccine·Albert Sabirov, Dennis W Metzger
Aug 28, 2007·Comparative Immunology, Microbiology and Infectious Diseases·Gilles MeyerFrançois Schelcher
Feb 1, 2012·Reviews in Medical Virology·Pablo A GonzálezAlexis M Kalergis
May 16, 2015·Nature Reviews. Immunology·Maria Kaparakis-Liaskos, Richard L Ferrero
Apr 28, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sihan WangZhenjia Wang
Apr 28, 2006·European Journal of Immunology·Falk Hiepe, Andreas Radbruch
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily K ForbesElma Z Tchilian
Mar 17, 2021·Molecular Immunology·William J GilmoreMaria Kaparakis-Liaskos

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