Intranasal influenza vaccine: Why does Canada have different recommendations from the USA on its use?

Paediatrics & Child Health
Theresa W S Tam

Abstract

Canada and the USA differ in their recommendations for the use of live attenuated influenza vaccine (LAIV). The Canadian National Advisory Committee on Immunization (NACI) continues to recommend LAIV as one of the influenza vaccines available for use in children 2 to 17 years of age. The US Advisory Committee on Immunization Practices (ACIP) made an interim recommendation against the use of LAIV for the 2016 to 2017 influenza season in response to low LAIV effectiveness observed in the USA during the 2013 to 2014 to 2015 to 2016 seasons. The recommendation has been continued for the 2017 to 2018 season. In response, NACI undertook a review of available LAIV effectiveness data in children and adolescents from Canada, the USA and a number of European countries. This commentary by Canada's Chief Public Health Officer summarizes the findings of that review and provides the rationale for Canada's current continued recommendation for LAIV use.

References

Aug 26, 2016·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfJoseph S Bresee
Sep 30, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Hanna NohynekJukka Jokinen
Sep 30, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Richard PebodyMaria Zambon
Aug 10, 2017·The New England Journal of Medicine·Michael L JacksonBrendan Flannery
May 18, 2018·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·W VaudryUNKNOWN National Advisory Committee on Immunization (NACI)

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Citations

Mar 20, 2020·Journal of the Pediatric Infectious Diseases Society·Geoffrey A Weinberg
May 6, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura MatrajtRustom Antia
Feb 16, 2020·Journal of Biomedical Science·Juine-Ruey ChenChe Ma
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jennifer NayakAubree Gordon

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