Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans.

Diabetes
Kamila Jauch-CharaKerstin M Oltmanns

Abstract

Cerebral insulin exerts anorexic effects in humans and animals. The underlying mechanisms, however, are not clear. Because insulin physiologically facilitates glucose uptake by most tissues of the body and thereby fosters intracellular energy supply, we hypothesized that intranasal insulin reduces food consumption via enhancement of the neuroenergetic level. In a double-blind, placebo-controlled, within-subject comparison, 15 healthy men (BMI 22.2 ± 0.37 kg/m(2)) aged 22-28 years were intranasally administered insulin (40 IU) or placebo after an overnight fast. Cerebral energy metabolism was assessed by (31)P magnetic resonance spectroscopy. At 100 min after spray administration, participants consumed ad libitum from a test buffet. Our data show that intranasal insulin increases brain energy (i.e., adenosine triphosphate and phosphocreatine levels). Cerebral energy content correlates inversely with subsequent calorie intake in the control condition. Moreover, the neuroenergetic rise upon insulin administration correlates with the consecutive reduction in free-choice calorie consumption. Brain energy levels may therefore constitute a predictive value for food intake. Given that the brain synchronizes food intake behavior in depe...Continue Reading

References

Jul 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P Bachert-BaumannW J Lorenz
Feb 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Erecińska, I A Silver
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanD L Rothman
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Feb 13, 1999·Science·P J MagistrettiR G Shulman
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Feb 17, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P B BarkerA J Shaka
May 7, 2002·Nature Neuroscience·Jan BornHorst L Fehm
May 22, 2002·Nature Neuroscience·Silvana ObiciLuciano Rossetti
Nov 12, 2002·Nature Medicine·Silvana ObiciLuciano Rossetti
Apr 17, 2004·Journal of Neurochemistry·Angus M Brown
Jun 3, 2004·Neuroscience and Biobehavioral Reviews·A PetersH L Fehm
Oct 27, 2004·Diabetes·Manfred HallschmidWerner Kern
Apr 28, 2005·Nature Neuroscience·Tony K T LamLuciano Rossetti
Jan 18, 2006·Nature Neuroscience·Wu HeLuciano Rossetti
Sep 19, 2006·Physiology & Behavior·Lynda M BrownStephen C Woods
Feb 3, 2007·Progress in Neurobiology·A PetersH L Fehm
Oct 11, 2007·Diabetes, Obesity & Metabolism·David Russell-Jones, Rehman Khan
Jan 31, 2008·The Journal of Clinical Endocrinology and Metabolism·Christian BenedictManfred Hallschmid
Apr 9, 2010·Nature Medicine·Tony K T Lam
Apr 15, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·André SchmollerKerstin M Oltmanns
Aug 20, 2010·The Journal of Clinical Endocrinology and Metabolism·Rosemarie KrugManfred Hallschmid
Jun 28, 2011·Biological Psychiatry·Ferdinand BinkofskiKerstin M Oltmanns

❮ Previous
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Citations

Jan 29, 2013·Physiology & Behavior·Stephen C Woods
Jun 25, 2014·Nature Reviews. Endocrinology·Susan MurrayNicole M Avena
Aug 31, 2013·Theoretical Biology & Medical Modelling·Britta GöbelMatthias Chung
Jan 11, 2014·Journal of Drug Targeting·Sumeet SoodK Gowthamarajan
Nov 13, 2013·Expert Opinion on Drug Delivery·Suzanne M de la Monte
Jul 25, 2015·Expert Opinion on Drug Delivery·Yongjun JiangXinfeng Liu
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shan LuoKathleen A Page
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Thomas SchererManfred Hallschmid
Feb 18, 2016·Neural Plasticity·Chuanming WangJin H Yan
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Shuai LiuStephanie L Borgland
Oct 16, 2015·Nature Reviews. Endocrinology·Martin HeniHans-Ulrich Häring
Jun 5, 2015·Translational Stroke Research·Vasileios-Arsenios LioutasVera Novak
Sep 30, 2014·Psychoneuroendocrinology·Diana S Ferreira de SáHartmut Schächinger
May 13, 2014·Neuroscience·K Jauch-Chara, K M Oltmanns
Feb 26, 2015·Diabetes·Dale S Edgerton, Alan D Cherrington
Aug 28, 2012·Diabetes·Paul Kievit, Jonathan Q Purnell
Sep 23, 2016·Molecular Metabolism·Seung-Hwan LeeYoung-Bum Kim
Nov 25, 2016·Journal of Neuroendocrinology·R Rodriguez-RaeckeJ Freiherr
Jul 21, 2015·PloS One·Sarah A EisensteinTamara Hershey
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Thomas SchererMichael Krebs
Mar 7, 2018·Diabetes, Obesity & Metabolism·Vera SchmidMartin Heni
Mar 3, 2018·The Journal of Experimental Biology·Clare C RittschofPatrick G Sullivan
Aug 5, 2016·Physiological Reviews·Stephanie KullmannHans-Ulrich Häring
Sep 22, 2017·Expert Review of Clinical Pharmacology·Hubertus Himmerich, Janet Treasure
Jul 4, 2018·Stress : the International Journal on the Biology of Stress·Alina KistenmacherKerstin M Oltmanns
Jun 22, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Maartje S Spetter
Aug 8, 2014·The American Journal of Clinical Nutrition·Kamila Jauch-CharaKerstin M Oltmanns
Jan 4, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bhavani KashyapWilliam H Frey Ii
Jan 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fiona BrabazonKimberly R Byrnes
Jun 29, 2017·Journal of Diabetes Research·Grazia Daniela FemminellaNicola Ferrara
Nov 1, 2017·Frontiers in Pharmacology·Ajna Hamidovic
Oct 4, 2018·European Eating Disorders Review : the Journal of the Eating Disorders Association·Marta G Novelle, Carlos Diéguez
Oct 26, 2018·Frontiers in Endocrinology·Rea Rodriguez-RaeckeJessica Freiherr
Apr 17, 2020·Nature Communications·Stephanie KullmannMartin Heni

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Software Mentioned

AMARES
Magnetic Resonance User Interface ( MRUI )
SPSS

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