Intranasal ketorolac: for short-term pain management.

Clinical Drug Investigation
Karly P Garnock-Jones

Abstract

Ketorolac is a member of the pyrrolo-pyrrole group of NSAIDs, and has been available in several formulations for some time, for the treatment of pain. Intranasal ketorolac has recently become available. Intranasal ketorolac was effective in providing short-term relief from postoperative pain in four well designed, phase II or III trials. In the two phase III trials, a single intranasal dose of ketorolac 31.5 mg, with or without backup analgesia, was associated with significantly higher 6-hour summed post-treatment pain intensity difference scores (primary endpoint) than placebo in adult patients with acute pain following major surgery, including abdominal and orthopaedic surgery. Intranasal ketorolac 31.5 mg up to three or four times daily for ≤5 days also had an opioid-sparing effect in these trials, with significantly less morphine used among ketorolac than among placebo recipients over the first 48 hours of treatment. Moreover, a greater proportion of ketorolac recipients experienced analgesia onset within 1 and 1.5 hours but not 2 hours than placebo recipients, indicating a more rapid onset with intranasal ketorolac. In adult patients with acute pain following major surgery, intranasal ketorolac 31.5 mg three or four times ...Continue Reading

References

Nov 21, 2008·Anesthesia and Analgesia·John E MoodieLincoln Bynum
Jul 15, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Colin BrownLincoln Bynum
Mar 9, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·George M Grant, Donald R Mehlisch
Jun 19, 2010·Current Medical Research and Opinion·Neil SinglaColin Brown
Jul 5, 2011·Drugs & Aging·Paul L McCormack

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Citations

Feb 5, 2019·Expert Opinion on Drug Metabolism & Toxicology·Chiara LupiAndrea Negro
Mar 7, 2019·Chemistry : a European Journal·Darya RadziukVladimir Labunov
Jul 18, 2021·Pain and Therapy·Filomena PuntilloGiustino Varrassi

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