Intranasal melatonin nanoniosomes: pharmacokinetic, pharmacodynamics and toxicity studies

Therapeutic Delivery
Aroonsri PripremNutjaree Prateepawanit Johns

Abstract

Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated. A formula of melatonin niosomes (MN) was selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics and toxicity studies in male Wistar rats. Intranasal MN was bioequivalent to intravenous injection of melatonin, providing therapeutic level doses. Acute and subchronic toxicity screening showed no abnormal signs, symptoms or hematological effects in any animals. Transient nasal irritations with no inflammation were observed with intranasal MN, leading it to be categorized as relatively harmless. The intranasal MN could deliver melatonin to the brain to induce sleep and provide delayed systemic circulation, relative to intravenous injection and also distribute to peripheral tissue.

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Citations

Apr 24, 2018·Therapeutic Delivery·Aroonsri PripremCheardchai Soontornpas
Jul 3, 2019·Pharmaceutical Research·Edilson Ribeiro de Oliveira JuniorEliana Martins Lima
Aug 28, 2019·Current Medicinal Chemistry·Areen AlshweiatIIdikó Csoka
Nov 24, 2018·Frontiers in Pharmacology·Nebojša PavlovićMomir Mikov
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibAsma Ismail Mahmod
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz Gustavo de Almeida ChuffaRussel J Reiter

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