Intranasal midazolam therapy for pediatric status epilepticus

The American Journal of Emergency Medicine
Timothy R Wolfe, Thomas C Macfarlane

Abstract

Prolonged seizure activity in a child is a frightening experience for families as well as care providers. Because duration of seizure activity impacts morbidity and mortality, effective methods for seizure control should be instituted as soon as possible, preferably at home. Unfortunately, parenteral methods of medication delivery are not available to most caregivers and rectal diazepam, the most commonly used home therapy, is expensive and often ineffective. This brief review article examines recent research suggesting that there is a better way to treat pediatric seizures in situations where no intravenous access is immediately available. Intranasal midazolam, which delivers antiepileptic medication directly to the blood and cerebrospinal fluid via the nasal mucosa, is safe, inexpensive, easy to learn by parents and paramedics, and provides better seizure control than rectal diazepam.

References

Mar 1, 1992·Epilepsia·C RemyP Genton
Sep 1, 1988·American Journal of Diseases of Children·J Y Yager, S S Seshia
Mar 1, 1982·British Journal of Clinical Pharmacology·S DhillonA Richens
Jun 1, 1993·British Journal of Anaesthesia·J M MalinovskyM Pinaud
May 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·O R HungD R Stanski
Jul 27, 1999·Epilepsia·D H Lowenstein
Sep 14, 2000·Seizure : the Journal of the British Epilepsy Association·M ScheepersM Ibitoye
Oct 24, 2000·Brain & Development·N O KutluY Durmaz
Feb 24, 2001·Journal of Child Neurology·T FişginD Akgün
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·O DaleE D Kharasch
Jan 8, 2004·Archives of Disease in Childhood·M T WilsonM E O'Regan
May 5, 2004·Epilepsy & Behavior : E&B·T Mahmoudian, M Mohammadi Zadeh
Sep 16, 2004·Journal of Paediatrics and Child Health·M G HarbordK P Coulthard
Jun 22, 2005·Current Treatment Options in Neurology·Trudy Pang, Lawrence J Hirsch

❮ Previous
Next ❯

Citations

Nov 9, 2012·Pharmaceutical Research·Colin D ChapmanChristian Benedict
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniel P Wermeling
Jan 26, 2008·The Neurologist·Juan José García PeñasJavier Salas Puig
Dec 18, 2013·Early Human Development·Julien BaleineGilles Cambonie
Feb 19, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet HardySimon Allan
Jul 21, 2009·Expert Opinion on Drug Metabolism & Toxicology·Ralph ClinckersOscar Della Pasqua
Aug 7, 2013·Emergency Medicine Clinics of North America·Maneesha Agarwal, Sean M Fox
Apr 7, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Judith P Lazol, Curt G DeGroff
Feb 25, 2009·Epilepsy & Behavior : E&B·Susanne KnakeFelix Rosenow
Oct 24, 2007·Emergency Medicine Clinics of North America·Michelle D Blumstein, Marla J Friedman
Oct 16, 2016·Emergency Medicine Clinics of North America·Danya Khoujah, Michael K Abraham
Sep 8, 2016·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Daniel Crawford
Jun 20, 2017·Emergency Medicine Australasia : EMA·Jeremy FurykFranz E Babl
Jan 6, 2018·Journal of Palliative Medicine·Samuel J PernaErin R Currie
Jan 1, 2012·Clinical Medicine Insights. Pediatrics·Ayşe UlgeyCihangir Bicer
May 2, 2015·Advanced Emergency Nursing Journal·Rachel Rogalski, Andrew Rogalski
Mar 28, 2020·Palliative Care and Social Practice·Eric Prommer
Jul 22, 2014·The Journal of Organic Chemistry·Tomasz SiodłaTadeusz M Krygowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.