Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness

Neuropharmacology
Francesca ZorattoGiovanni Laviola

Abstract

Deficits in empathy, the ability to share an emotion of another individual, constitute a hallmark of several psychopathological conditions, including conduct disorder. The co-occurrence of excess rates of aggression, general violation of societal norms and callous-unemotional traits confers specific risk for adult psychopathy. In the present study, we relied on a recently devised experimental model of conduct disorder in mice to test the potential efficacy of intranasal oxytocin administration. Two subgroups of BALB/cJ male mice exhibiting opposite profiles in emotional contagion (i.e. socially transmitted adoption of another's emotional states) underwent a series of tests mapping onto reactive aggression, information processing, perseverative behaviour, punishment-related emotional memory, physiological arousal and hormonal stress reactivity, with or without intranasal oxytocin administration (5.0 or 20.0 μg/kg). Collectively, our data indicate that a trait of markedly reduced emotional contagion is associated with a behavioural syndrome of sensorimotor gating deficits, impaired emotional memory, increased aggression and stereotyped behaviours, dysregulations in the circadian rhythms of activity and body temperature and dampen...Continue Reading

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Citations

Nov 30, 2019·Animals : an Open Access Journal From MDPI·Chiara ScopaPaolo Baragli
Nov 3, 2020·Behavioural Pharmacology·Stewart S Cox, Carmela M Reichel
Mar 24, 2021·Current Opinion in Neurobiology·Enrica ParadisoChristian Keysers
Jun 28, 2021·Psychoneuroendocrinology·Giovanni LaviolaMarco Fiore
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Valentina ChiodiManlio Vinciguerra

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