Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Jessie L FrijlingMiranda Olff

Abstract

Approximately 10% of trauma-exposed individuals go on to develop post-traumatic stress disorder (PTSD). Neural emotion regulation may be etiologically involved in PTSD development. Oxytocin administration early post-trauma may be a promising avenue for PTSD prevention, as intranasal oxytocin has previously been found to affect emotion regulation networks in healthy individuals and psychiatric patients. In a randomized double-blind placebo-controlled between-subjects functional magnetic resonance (fMRI) study, we assessed the effects of a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individuals within 11 days post trauma. Two resting-state scans were acquired; one after neutral- and one after trauma-script-driven imagery. We found that oxytocin administration reduced amygdala-left vlPFC FC after trauma script-driven imagery, compared with neutral script-driven imagery, whereas in PL-treated participants enhanced amygdala-left vlPFC FC was observed following trauma script-driven imagery. Ir...Continue Reading

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Citations

Dec 25, 2015·Psychopharmacology·Chantelle L FerlandJacqueline F McGinty
Aug 2, 2017·Brain Connectivity·Katja BrodmannRoberto Goya-Maldonado
Aug 9, 2016·Social Cognitive and Affective Neuroscience·Regan M BernhardJoshua D Greene
Mar 17, 2018·Frontiers in Pharmacology·Mariana Fortunata DonadonFlávia de Lima Osório
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Jan 11, 2020·General Psychiatry·Elizabeth HogeNaomi Simon
Oct 12, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·April AlcantaraDaniel H S Silverman

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