Intranasal oxytocin reduces weight gain in diet-induced obese prairie voles

Physiology & Behavior
Adele M SeelkeJames E Blevins

Abstract

Oxytocin (OT) elicits weight loss in diet-induced obese (DIO) rodents, nonhuman primates and humans by reducing food intake and increasing energy expenditure. In addition to being important in the regulation of energy balance, OT is involved in social behaviors including parent-infant bonds, friendships, and pair bonds. However, the impact of social context on susceptibility to diet-induced obesity (DIO) and feeding behavior (including food sharing) has not been investigated in a rodent model that forms strong social bonds (i.e. prairie vole). Our goals were to determine in Prairie voles (Microtus ochrogaster) whether i) social context impacts susceptibility to DIO and ii) chronic intranasal OT reverses DIO. Voles were housed in divided cages with holes in the divider and paired with a same-sex animal with either the same food [high fat diet (HFD)/HFD, [low fat diet (LFD; chow)/chow], or the opposite food (HFD/chow or chow/HFD) for 19 weeks. HFD-fed voles pair-housed with voles maintained on the HFD demonstrated increased weight relative to pair-housed voles that were both maintained on chow. The study was repeated to determine the impact of social context on DIO susceptibility and body composition when animals are maintained o...Continue Reading

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Citations

Oct 28, 2019·Journal of Neuroendocrinology·Elizabeth A LawsonJames E Blevins
Jan 14, 2020·Genome Génome / Conseil National De Recherches Canada·Yuanlang WangYueyun Ding
May 4, 2020·Neuroscience and Biobehavioral Reviews·Serenella TolomeoRichard P Ebstein
Dec 15, 2020·Biochimica Et Biophysica Acta. General Subjects·Shruti MohanR Charlotte Moffett
Jun 26, 2021·Current Protocols·William M KenkelAnnaliese K Beery

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