Intranasal topical estrogen in the management of epistaxis in hereditary hemorrhagic telangiectasia

Acta Oto-laryngologica
Kazuhiko Minami, Tomoyuki Haji

Abstract

Application of topical estriol ointment is an effective treatment for hereditary hemorrhagic telangiectasia (HHT) epistaxis. HHT is an autosomal-dominant disease characterized by epistaxis in more than 96% of patients. Management of this major symptom, epistaxis, has not been standardized. This study reports experience with topical application of estriol in patients with HHT. Five patients with a confirmed diagnosis of HHT who first visited the hospital between 2012 and 2013 received 0.1% estriol ointment and were guided to apply the ointment twice daily to the anterior part of both nasal cavities. Severity of epistaxis was valued using epistaxis severity score (ESS) before and 3 months after initiating therapy. Five patients (three males, two females) received treatment. After the initiation of treatment, intensity and frequency of epistaxis became moderate in all patients. ESS decreased significantly from pre- to post-treatment (p = 0.043). No adverse events were recorded during follow-up.

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Citations

Feb 3, 2018·International Forum of Allergy & Rhinology·Ashleigh A HaldermanBradley F Marple
Sep 12, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Yuan-Pin HsuChiehfeng Chen
Nov 15, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Michael D Lupa, Sarah K Wise

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