Intranasal vaccination with poly(lactide-co-glycolide) microparticles containing a peptide T of Ole e 1 prevents mice against sensitization

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
E G MarazuelaEva Batanero

Abstract

Biodegradable microparticles, in particular poly(lactide-co-glycolide) (PLGA), have been shown as potential delivery vehicles for intranasal (i.n.) vaccines in animal models. To evaluate whether i.n. administration of PLGA microparticles containing a peptide with the major T cell epitope of Ole e 1, the main allergen of olive pollen, prevented mice from allergic sensitization to the whole protein. Peptide-PLGA microparticles were prepared by a solvent evaporation double emulsion method. Microparticles in a size range of 0.8 mum were evaluated for peptide loading and in vitro antigen release. Stability and immunogenicity of the entrapped peptide were retained, as determined by dot blot and ELISA inhibition. BALB/c mice were intranasally treated with peptide-PLGA microparticles for 3 consecutive days, 1 week before sensitization/challenge to Ole e 1. Blood, lungs and spleen were collected and analysed for immune response. Biodistribution of microparticles was investigated using confocal microscopy. I.n. pretreatment of BALB/c mice with peptide-PLGA microparticles before sensitization to Ole e 1 led to a significant inhibition of serum allergen-specific IgE and IgG1 antibody levels, but a marked increase of specific IgG2a antibodi...Continue Reading

References

Jun 1, 1992·Immunology Today·C F KuperT Sminia
Sep 15, 1993·European Journal of Biochemistry·M VillalbaR Rodríguez
Sep 1, 1996·Immunological Investigations·R M CarrN L O'Sullivan
Nov 1, 1996·International Archives of Allergy and Immunology·G LiccardiG D'Amato
Jun 26, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B CárdabaC Lahoz
Oct 21, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·C D PartidosM W Steward
Jun 6, 2000·Advanced Drug Delivery Reviews·Y Huang, M D Donovan
Jun 6, 2000·Advanced Drug Delivery Reviews·R K Gupta
Nov 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·T HaoM L Hedley
Nov 8, 2001·Journal of Drug Targeting·J BrookingL Illum
May 22, 2002·International Archives of Allergy and Immunology·Eva BataneroRosalía Rodríguez
Jul 3, 2002·Nature Reviews. Immunology·Rudolf Valenta
Sep 14, 2002·Infection and Immunity·Libuse JanakovaBjørn Haneberg
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hae-Sun ParkP Patrick Cleary
Nov 25, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·B R GrubbR C Boucher
Feb 6, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elizabeth C TePasDale T Umetsu
Feb 28, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I SchöllE Jensen-Jarolim
Sep 3, 2004·Nature Reviews. Immunology·Hiroshi Kiyono, Satoshi Fukuyama
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·James N Francis, Stephen R Durham
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Isabella SchöllErika Jensen-Jarolim
Jun 9, 2005·Molecular Immunology·Eva María GonzálezRosalía Rodríguez
Oct 27, 2005·Current Drug Targets. Inflammation and Allergy·Ursula Wiedermann
Oct 27, 2005·Current Drug Targets. Inflammation and Allergy·Richard WeissJosef Thalhamer
Mar 28, 2006·Advanced Drug Delivery Reviews·Erin L Giudice, James D Campbell
Jul 5, 2006·International Reviews of Immunology·Heather L WilsonGeorge K Mutwiri
Jul 26, 2006·International Archives of Allergy and Immunology·Oscar PalomaresRudolf Valenta

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Citations

Dec 17, 2008·Pharmaceutical Research·Esmaiel Jabbari
Mar 5, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·William R Reisacher, Dara Liotta
Aug 27, 2011·Respiratory Research·Berislav BosnjakMichelle M Epstein
Dec 14, 2011·Expert Review of Vaccines·Richard WeissJosef Thalhamer
Dec 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C AlmqvistJ Woodfolk
Oct 14, 2010·Cell Biochemistry and Function·Maria Augusta RoosAntonio Ponzetto
Aug 8, 2013·Methods : a Companion to Methods in Enzymology·Mayte VillalbaEva Batanero
Mar 6, 2012·Talanta·C EsteveM C García
Jan 7, 2010·PloS One·Viswanathan PalanisamyDavid T Wong
Mar 26, 2014·Biomacromolecules·Alice W Du, Martina H Stenzel
Sep 14, 2016·Annual Review of Pharmacology and Toxicology·Carles Corbi-VergePhilip M Kim
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noela PradoEva Batanero
Aug 28, 2020·Frontiers in Immunology·Isabella Pali-SchöllErika Jensen-Jarolim
Jan 29, 2020·Molecular Pharmaceutics·Sara BenedéEva Batanero
Aug 23, 2021·Current Opinion in Allergy and Clinical Immunology·Alessandra LongoPaolo Colombo

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