PMID: 6185674Jan 1, 1981Paper

Intranuclear transformation of the estrogen receptor in adulthood: tissue and species similarities

Journal of Receptor Research
D M Linkie


Previous studies in immature rodents have demonstrated the presence of two forms (4S, 5S) of salt extractable estrogen receptor in uterine nuclear preparations. The link between these binding forms appears to be that of hormone dependence and time in a precursor-product relationship. In the present study, this relationship has been observed in nuclear extracts of the uterus and anterior pituitary of intact and gonadectomized adult rats. Both forms of the estrogen receptor have also been isolated from purified nuclei of endometrial cell preparations of the adult dog. As a result of these studies, the phenomenon of intranuclear receptor transformation in estrogen action may now be extended to include (a) the physiologic state of adulthood, (b) persist in the absence of endogenous estrogens and (c) be a feature of estrogen target tissues in animal species other than rodents.


Nov 1, 1978·Journal of Steroid Biochemistry·D M Linkie, P K Siiteri
May 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·D M Linkie, A R LaBarbera
Jul 1, 1979·Journal of Steroid Biochemistry·E A NunezJ Delorme
Nov 5, 1979·Life Sciences·D M Linkie, A R LaBarbera
Oct 12, 1973·Science·E V Jensen, E R DeSombre
Jan 1, 1973·Advances in Experimental Medicine and Biology·P K SiiteriP C MacDonald
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·K R Yamamoto, B M Alberts

❮ Previous
Next ❯


Mar 1, 1986·Journal of Steroid Biochemistry·A D LinstedtR M Brenner

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.